Novel combination of bioactive agents in bilayered dermal patches provides superior wound healing

Two-photon polymerization based reusable master template to fabricate polymer microneedles for drug delivery

“…Briefly, 1 × 105 HADF cells/well were cultured in a 96-well plate for 24 h after which 6 mm punches of the patches were kept on top of the monolayer of cells for 72 h. MTT assay was performed as per Pillai et al. [12] . To study the effect of degradation products of microneedle patches on cells, supernatants of patches incubated in SBF, were collected at different time intervals and incubated with HADF cells to assess their cytocompatibility.…”

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

“…Unfortunately, the use of curcumin is limited by its low bioavailability, rapid metabolism, poor solubility, and light sensitivity [ 152 ]. A large number of recent papers [ 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 ] reported the incorporation of curcumin into nanocomposite materials such as nanofibers, nanoparticles, hydrogels, or novel combinations of these. Recently, numerous researchers have developed biocompatible and biodegradable composite nano-fibrous materials and hydrogel systems containing curcumin for wound healing applications, for example as an anti-scar or in chronic wounds [ 166 , 169 ].…”

“…Finally, the top layer, consisting of Ag nanoparticles, silk fibroin, and PCL, released Ag nanoparticles, which acted against external bacteria [ 176 ]. In a further study, when the eggshell membrane, a highly proteinaceous thin layer present between the egg white and shell, was added to the bottom layer made up of PVA with curcumin nanoparticles, antioxidant and anti-inflammatory action was implemented with positive effects on the migration of dermal fibroblasts [ 177 ]. This patch contributed to wound healing by providing exudate absorption, releasing therapeutical components, and supporting the deposition of extracellular matrix [ 177 , 178 ].…”

Polysaccharide Electrospun Nanofibers for Wound Healing Applications

“…136 The use of dressing materials to modulate the wound inflammatory microenvironment, including ROS removal, adsorption of inflammatory factors, and regulation of the phenotype and number of immune cells, can reduce the inflammatory response of the wound and accelerate the healing of chronic wounds. 137,138 Therefore, polysaccharide electrospun nanofibers with the ability to regulate the wound inflammatory microenvironment have great potential in the treatment of chronic wounds. 139,140 Honey is an ancient natural wound-healing agent with antibacterial, antioxidant and anti-inflammatory properties that has been reintroduced into modern clinical wound care.…”