The paper ‘A C‐Terminal Fragment of Adhesion Protein Fibulin‐7 Inhibits Growth of Murine Breast Tumor by Regulating Macrophage Reprogramming’ by Chakraborty et al. highlights that Fbln7‐C could be explored as a potential immunomodulatory agent against various solid cancers and have shown its abilities to regulate tumor microenvironment reprogramming of TAMs in a breast cancer model. Fbln7, which is a secreted glycoprotein, has been shown to be anti‐angiogenic and has an immunomodulatory role regulating various functional properties of monocytes, macrophages, and neutrophils, thereby influencing inflammation. In this study, the authors have shown that in a murine breast tumor model, intravenous administration of Fbln7‐C significantly reduces the size of tumors via macrophage reprogramming.
Comment on: https://doi.org/10.1111/febs.15333.
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