Novel Cellulose Fibre-Based Flexible Plasmonic Membrane for Point-of-Care SERS Biomarker Detection in Chronic Wound Healing

Perumal, Jayakumar; Lim, Hann Qian; Attia, Amalina Binte Ebrahim; Raziq, Riazul; Leavesley, David I.; Upton, Zee; Dinish, U. S.; Olivo, Malini

doi:10.2147/ijn.s303130

Cited by 13 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The volatile compounds successfully differentiate between the pathogens studied, which can be developed as rapid point-of-care diagnostics for wound infection. Although studies are limited to biomarkers that are unique to bacterial biofilms, especially those present in multiple bacterial species, but detection of biofilm matrix components (such as cellulose (Perumal et al, 2021)) and QS signal profiling might discover potential biomarkers. Other novel approaches, including targeted nanopore sequencing (TNPseq) (Zhang et al, 2022a); metagenomics (Taşet al, 2021); and nanoparticles (Funari and Shen, 2022).…”

Section: Detection and Monitor Of Biofilm Formationmentioning

confidence: 99%

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Pai,

Patil,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Biofilms are a common survival strategy employed by bacteria in healthcare settings, which enhances their resistance to antimicrobial and biocidal agents making infections difficult to treat. Mechanisms of biofilm-induced antimicrobial resistance involve reduced penetration of antimicrobial agents, increased expression of efflux pumps, altered microbial physiology, and genetic changes in the bacterial population. Factors contributing to the formation of biofilms include nutrient availability, temperature, pH, surface properties, and microbial interactions. Biofilm-associated infections can have serious consequences for patient outcomes, and standard antimicrobial therapies are often ineffective against biofilm-associated bacteria, making diagnosis and treatment challenging. Novel strategies, including antibiotics combination therapies (such as daptomycin and vancomycin, colistin and azithromycin), biofilm-targeted agents (such as small molecules (LP3134, LP3145, LP4010, LP1062) target c-di-GMP), and immunomodulatory therapies (such as the anti-PcrV IgY antibodies which target Type IIIsecretion system), are being developed to combat biofilm-induced antimicrobial resistance. A multifaceted approach to diagnosis, treatment, and prevention is necessary to address this emerging problem in healthcare settings.

show abstract

Section: Detection and Monitor Of Biofilm Formationmentioning

confidence: 99%

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Pai,

Patil,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…205 Perumal et al developed a biofunctionalized flexible, cost-effective, scalable, and easy-to-fabricate plasmonic SERS substrate using cellulose fiber, which could be incorporated into wound dressings in the future for routine monitoring of wound healing status. 206 He and his colleagues achieved non-invasive, highly-sensitive detection and long-term tracking of residual bacteria in wounds using gold-silver-nanoshells-based SERS. 207…”

Section: Wound Infection Monitoringmentioning

confidence: 99%

Optical biosensing systems for a biological living body

Yan

Guo

Wang

et al. 2023

VIEW

View full text Add to dashboard Cite

With the development of technology, biosensors are increasingly used in the biomedical field. Due to the high sensitivity of optical signals, good stability, high signal‐to‐noise ratio, and different spectral characteristics of different analytes, optical biosensors can achieve direct and real‐time detection of analytes with high specificity compared with traditional analytical techniques. In view of the rapid development of optical biosensors for in vivo applications and their promising future, we have attempted to summarize the working principles and recent advances in application in humans, with the aim of helping readers to gain an in‐depth and detailed understanding of optical biosensors developed in recent years for applications in the biological living body. In this review, we focus on some of the current widely used and promising optical biosensors, including colorimetric biosensors, fluorescence biosensors, and surface‐enhanced‐Raman‐scattering‐based biosensors. The working principles for each type of optical biosensor are concisely described and the application of the biosensor in the living body is summarized by category. We conclude by looking at the prospects of in vivo applications of optical biosensors.

show abstract

“…Olivo et al added AgNPs to a fiber-based membrane monitor to increase the active surface area in the sensor, improving the detection sensitivity for biomarkers in the wound area. 219 In order to avoid secondary wound damage caused by dressing changes, Jiang et al created bacterial cellulose-based membranes with aminobenzeneboronic acid-modified gold nanoclusters (A-GNCs), which could be used for treating wounds infected with multidrug-resistant bacteria. 220 A-GNCs emit bright orange fluorescence under UV light, and the intensity of this fluorescence decreases with the release of A-GNCs.…”

Section: Nanoplatforms For Chronic Wound Healingmentioning

confidence: 99%

Nanobiotechnology: Applications in Chronic Wound Healing

Jiang¹,

Li²,

Qiu³

et al. 2022

IJN

View full text Add to dashboard Cite

Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.

show abstract

Novel Cellulose Fibre-Based Flexible Plasmonic Membrane for Point-of-Care SERS Biomarker Detection in Chronic Wound Healing

Cited by 13 publications

References 50 publications

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Optical biosensing systems for a biological living body

Nanobiotechnology: Applications in Chronic Wound Healing

Contact Info

Product

Resources

About