Nanobiotechnology: Applications in Chronic Wound Healing

Abstract

Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.

Advancements and applications of upconversion nanoparticles in wound dressings

“…Recently, smart wound dressings that integrate wearable sensors and drug delivery systems have been introduced for wound healing applications. 14,15 UCNPs can be tailored to emit specific wavelengths, intensities, and stability, enabling customization for different wound healing requirements. Surface modifications can be employed to enhance their functionalization, such as incorporating antibacterial agents or drug payloads.…”

Os Desafios Na Conduta Terapêutica Em Pacientes Acometidos Com Feridas Crônicas

“…Os métodos tradicionais para tratar esta patologia consistem na administração de medicamentos locais ou sistêmicos, no entanto possuem baixa solubilidade e bioatividade. O desenvolvimento de nanopartículas alavanca o sistema de entrega dos fármacos podendo fornecer efeitos terapêuticos aprimorados, além do que sua liberação é controlada, possui uma melhora da aderência no local reduzindo as aplicações durante os dias e os custos do tratamento (JIANG et al, 2022).…”

Insulin-like Growth Factor-2 (IGF-2) in Fibrosis

“…In addition, as a growth factor that promotes periodontal and fracture healing [ 26 , 27 ], IGF-2 is involved in the repair process of tissue injuries. During the development of skin wound healing, keratinocytes synthesize IGF-2 to promote tissue repair in an autocrine or paracrine manner [ 28 , 29 ]. The IGF-2 precursor encoded by the IGF-2 gene is a single-chain polypeptide consisting of an amino-terminal signal peptide (24 amino acids) and a carboxyl-terminal E domain (89 amino acids).…”