Novel anti-inflammatory and wound healing controlled released LDH-Curcumin nanocomposite via intramuscular implantation, in-vivo study

Mahmoud, Rehab; Safwat, Nesreen M.; Fathy, Mouhamed; Khaled, Rehab; El-Dek, S.I.; El-Banna, H. A.; Farghali, Ahmed A.; El-Ela, Fatma I. Abo

doi:10.1016/j.arabjc.2021.103646

Cited by 17 publications

(16 citation statements)

References 39 publications

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“…59 Moreover, zinc-aluminum layered double hydroides (LDH), curcumin, and curcumin nanohybrids revealed good tissue repair in acute and chronic wounds with good biocompatibility and healing activity with collagen formation, in addition to prolongation of the duration of action of the loaded materials or drugs with LDH nanomaterial in a controlled release manner. 60 Our results agree with the findings by Jamaran and Zarif (2016) who investigated the synergistic wound healing activity of neomycin and silver within the gel matrix. 61 Kumar et al (2016) reported that tetracycline conjugated Ag-NPs increased the antibacterial action of tetracycline due to enhanced Ag+ accumulation around bacterial cell membranes.…”

Section: Discussionsupporting

confidence: 92%

“… 59 Moreover, zinc–aluminum layered double hydroides (LDH), curcumin, and curcumin nanohybrids revealed good tissue repair in acute and chronic wounds with good biocompatibility and healing activity with collagen formation, in addition to prolongation of the duration of action of the loaded materials or drugs with LDH nanomaterial in a controlled release manner. 60 …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the wound healing effect of neomycin-silver nano-composite gel in rats

Banna

Youssef

Elzorba

et al. 2022

Int J Immunopathol Pharmacol

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Objectives: Both nano silver and neomycin have wound healing properties. Silver nanoparticles have been used as main compounds for therapeutic drug delivery systems against various ailments. The present study aimed to prepare a neomycin silver nano-composite gel easily, rapidly, and cheaply method to improve wound healing. Methods: Forty-five Wistar rats (150–200 g) divided into nine groups: wound untreated, wound fusidic acid treated, wound neomycin treated, three groups with wound and neomycin silver nano-composite gel at 1:1, 1:2, and 1:3 concentrations, respectively, and three groups wound treated silver nano gel at the previous concentrations, respectively. Percentages of wound healing and histopathological examination of the wound area were assessed in all groups. Results: Atomic force microscopy (AFM) and transmission electron microscopy (TEM) images demonstrated the spherical shape of neomycin silver nano-composite gel without aggregation but homogenous dispersion in a gel matrix. Dynamic light scattering (DLS) showed a 4 nm size of nano silver, which agrees with AFM image data analysis but not with TEM image due to the good coating of the gel matrix to silver nanoparticles. Dynamic light scattering Zeta potential was −21 mV, illustrating the high bioactivity of the neomycin silver nano-composite. The groups receiving neomycin silver nano-composite gel showed a significantly higher and dose dependent wound healing compared to other treatment groups. Conclusion: The present work confirmed the potential wound healing activity of neomycin silver nano-composite gel compared to either alone.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evaluation of the wound healing effect of neomycin-silver nano-composite gel in rats

Banna

Youssef

Elzorba

et al. 2022

Int J Immunopathol Pharmacol

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“…− , or organic anions. 5 LDHs have attracted much interest in recent years as adsorbents due to having large specific surface area, low toxicity, high anion substitution capacity, ease of recoverability, economic production, and high stabilities for chemical and thermal properties. 6 Laipan et al 7 prepared a CuFe LDH using a simple coprecipitation method and used it as an adsorbent for oil as a model organic contaminant.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies are available in the open literature reporting the reuse of spent layered double hydroxides (LDHs) or the corresponding mixed metal oxide (MMO) adsorbents in the field of further environmental remediation. LDHs are two-dimensional (2D) anionic clay materials with a structure similar to brucite and chemical formula [M(II)(1 – x )M( III ) x (OH)2] x + (A n – ) x / n · y H 2 O. M(II) is a divalent cation such as Mg, Ni, Zn, Cu, or Co and M(III) is a trivalent cation such as Al, Cr, Fe, or Ga, while A n – is negative anions such as CO 3 –2 , Cl – , NO 3 – , or organic anions . LDHs have attracted much interest in recent years as adsorbents due to having large specific surface area, low toxicity, high anion substitution capacity, ease of recoverability, economic production, and high stabilities for chemical and thermal properties .…”

Section: Introductionmentioning

confidence: 99%

“…LDHs are two-dimensional (2D) anionic clay materials with a structure similar to brucite and chemical formula [M(II)(1 – x )M( III ) x (OH)2] x + (A n – ) x / n · y H 2 O. M(II) is a divalent cation such as Mg, Ni, Zn, Cu, or Co and M(III) is a trivalent cation such as Al, Cr, Fe, or Ga, while A n – is negative anions such as CO 3 –2 , Cl – , NO 3 – , or organic anions. 5 LDHs have attracted much interest in recent years as adsorbents due to having large specific surface area, low toxicity, high anion substitution capacity, ease of recoverability, economic production, and high stabilities for chemical and thermal properties. 6 Laipan et al 7 prepared a CuFe LDH using a simple coprecipitation method and used it as an adsorbent for oil as a model organic contaminant.…”

Section: Introductionmentioning

confidence: 99%

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Waste Valorization of a Recycled ZnCoFe Mixed Metal Oxide/Ceftriaxone Waste Layered Nanoadsorbent for Further Dye Removal

et al. 2022

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Waste valorization of spent wastewater nanoadsorbents is a promising technique to support the circular economy strategies. The terrible rise of heavy metal pollution in the environment is considered a serious threat to the terrestrial and aquatic environment. This led to the necessity of developing cost-effective, operation-convenient, and recyclable adsorbents. ZnCoFe mixed metal oxide (MMO) was synthesized using co-precipitation. The sample was characterized using X-ray powder diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. Factors affecting the adsorption process such as pH, the dose of adsorbent, and time were investigated. ZnCoFe MMO showed the maximum adsorption capacity of 118.45 mg/g for ceftriaxone sodium. The spent MMO was recycled as an adsorbent for malachite green (MG) removal. Interestingly, the spent adsorbent showed 94% removal percent for MG as compared to the fresh MMO (90%). The kinetic investigation of the adsorption process was performed and discussed. In addition, ZnCoFe MMO was tested as an antimicrobial agent. The proposed approach opens up a new avenue for recycling wastes after adsorption into value-added materials for utilization in adsorbent production with excellent performance as antimicrobial agents.

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Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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Novel anti-inflammatory and wound healing controlled released LDH-Curcumin nanocomposite via intramuscular implantation, in-vivo study

Cited by 17 publications

References 39 publications

Evaluation of the wound healing effect of neomycin-silver nano-composite gel in rats

Evaluation of the wound healing effect of neomycin-silver nano-composite gel in rats

Waste Valorization of a Recycled ZnCoFe Mixed Metal Oxide/Ceftriaxone Waste Layered Nanoadsorbent for Further Dye Removal

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

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