Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Abstract

Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

Bletilla striata composite nanofibrous membranes prepared by emulsion electrospinning for enhanced healing of diabetic wounds

“…This maintains a proper wet environment, promoting wound healing. 39 In order to confirm the core-shell structure of the prepared fibers, the fibers were deposited directly on a copper mesh plate and observed by TEM. As shown in Figure 3(b), micrographs showed that the core-shell chains were successfully obtained by emulsion electrospinning with smooth surfaces and distinct boundaries together with the fibers, indicating the formation of the desired core-shell structure.…”

Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

“…Nano-formulations are commonly developed for a wide variety of applications in the biomedical area such as specific analyte detection [ [69] , [70] , [71] ], specific disorder diagnosis [ 72 ], targeted delivery and co-delivery of therapeutic agents [ 73 ], efflux pump circumvention [ 74 , 75 ] as well as preventing embedded drugs' enzymatic degradation, adjusted drug release, improving pharmacokinetics, and enhancing the wound-healing efficacy [ 76 , 77 ]. Accordingly, nanotechnology is the vanguard for the improvement of the solubility and bioavailability of aqueous insoluble drugs/compounds.…”

Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

“…This is attributed to its low solubility in water and rapid breakdown in the body. To overcome these barriers, the research is focused on developing innovative delivery mechanisms such as nanotechnology-based systems, liposomal encapsulation, and phytosomal formulations, aiming to enhance its absorption and efficacy [ 6 , 7 ].…”