Normoalbuminuric diabetic kidney disease: a distinct entity?

Madhu, SV

doi:10.1007/s13410-019-00751-0

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…eGFR was better correlated with BH, CH than Proteinuria. This in line with the concept of existence of nonalbuminuric kidney disease[15] and the same can be measured in terms of quantitative eGFR. Thus, eGFR is considered a better variable than macroproteinuria that is significant in our setups, where microalbuminuria testing is difficult to implement.…”

Section: Discussionsupporting

confidence: 78%

Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy

Solanki

Patel

Hadiyel

et al. 2019

J Family Med Prim Care

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Introduction:Diabetes mellitus (DM) is a significant risk factor for nephropathy and cardiovascular morbidity. Pulse wave analysis (PWA) gives direct inference of brachial hemodynamics (BH) and central hemodynamics (CH). We studied relation of them with diabetic nephropathy (DN) among type-2 diabetics (T2D).Methods:We studied oscillometric PWA by a cross-sectional study in 160 T2Ds. Using Mobil-o-Graph (IEM, Germany), we derived BH (blood pressure, pulse pressure index, rate pressure product) and CH (aortic pressure, cardiac index, stroke volume index, stroke work). They were further compared and associated with DN in terms of creatinine, proteinuria, and estimated glomerular filtration rate (eGFR).Results:There were 89 males, mean age 56 years, mean duration 4.8 years, 80% hypertensive predominantly using ACE inhibitors, poor glycemic blood pressure (BP) control, mainly mild-to-moderate DN, mean eGFR 88.2, 34% prevalence of proteinuria. Arterial stiffness was high with female disadvantage. BH and CH parameters were not different with or without DN using proteinuria or eGFR (60 cutoff) criteria. BH, CH correlated insignificantly with creatinine and eGFR. Female disadvantage, correlation with bSBP and aSBP were only significant results.Conclusions:BH and CH are not related to eGFR and proteinuria in predominantly hypertensive, Gujarati diabetics with mild-to-moderate nephropathy suggesting need of other cardiovascular parameters.

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Section: Discussionsupporting

confidence: 78%

Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy

Solanki

Patel

Hadiyel

et al. 2019

J Family Med Prim Care

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“…It converts angiotensin I to angiotensin II active peptide, leading to increased hematopoietic stem cells [12]. Single nucleotide polymorphisms (SNPs) of renin-angiotensin system (RAS) genes, such as ACE I/D genotype is significantly associated with cardiovascular disease (CVD) development [13,14]. Our objective was assessment the relationship of angiotensin converting enzyme (I/D) polymorphism (rs4646994) and male Iraqi CHD patients with T2DM compared to the healthy control population.…”

Section: Introductionmentioning

confidence: 99%

Relationship of angiotensin converting enzyme (I/D) polymorphism (rs4646994) and coronary heart disease among a male Iraqi population with type 2 diabetes mellitus

Hemeed

Al-Tu’ma

Al-Koofee

et al. 2020

J Diabetes Metab Disord

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Background Insertion deletion (I/D) polymorphism (rs4646994) in the angiotensin-converting enzyme (ACE) has a substantial effect on coronary heart disease (CHD). The amplification of an Alu repetitive element in an intron of the ACE has shown three potential genotypes of I/I and D/D as homozygous, and I/D as heterozygous.Objective The objective of this study was to investigate the association between the ACE gene polymorphism and CHD among male Iraqi patients with and without type2 diabetes mellitus (T2DM). Methods A case-control study of total 217 male subjects participated in this study, divided into three groups; Group 1 including 86 CHD patients with T2DM, group 2 including 78 CHD patients without T2DM, and group 3 including 53 age and sex-matched healthy individuals (as a control group). Genotyping of ACE (I/D) gene was performed using polymerase chain reaction (PCR) technique. ResultsThe II allele was significantly more frequent in CHD patients without T2DM compared to the control population, but not from those patients with T2DM (p < 0.05). Nonetheless, the ID allele was significantly more frequent in each of CHD with T2DM and control populations compared to the CHD without T2DM. The DD allele was significantly more frequent in CHD patients with T2DM compared to each of CHD patients without T2DM and control populations (p < 0.05). Conclusion We conclude that the D/D and I/D genotypes are implicated as risk factors for development of CHD with T2DM, but not CHD without T2DM among the male Iraqi population. However, larger sample sizes are needed to monitor the CHD patients and to validate this study.

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“…Intrarenal arteriosclerosis is the chief cause of renal impairment in type 2 diabetes mellitus and this may cause eGFR declines in these patients. 15 Pappitha Raja found a positive correlation between albuminuria and dysregulation of glomerular pore size. 16 On the basis of these references, findings of our study may be explained as follows.…”

Section: Discussionmentioning

confidence: 99%

A study of microalbuminuria in patients with type 2 diabetes mellitus, visiting tertiary care center Sangli

Belwalkar¹,

Jagtap²,

Mane³

et al. 2022

IJCBR

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Diabetic nephropathy is accompanied with significant micro vascular risk and is the leading cause of kidney disease. Hence there is an immense need to detect early for better quality of the care of affected patients and treat effectively those at high risk of diabetic kidney disease. Our study was aimed to assess the levels of microalbuminuria, glycated hemoglobin, urinary creatinine, urinary albumin to creatinine ratio (ACR) along with blood urea and serum creatinine in patients with type 2 DM, and to observe the incidence of microalbuminuria at tertiary care center; and correlate the presence of microalbuminuria to the duration of DM as well as with ACR. : Estimation of Blood sugar, Blood Urea, Serum Creatinine, Glycosylated hemoglobin (HbA1c), Urinary micro albumin and creatinine was done. Values of urinary creatinine, microalbumin, urinary albumin to creatinine ratio (ACR) showed highly significant (p<0.000) difference between the two age groups a) below 60 years and b) above 60 years of the age. Highly significant difference (p<0.000) was found among the results of the three groups based on duration of diabetes. We found microalbuminuria was more predominant in patients having age more than 60 years as well as in patients having more than 10 years of duration of DM. Routine screening for microalbuminuria in type 2 diabetic patients will certainly helpful for early detection of renal damage and thus to minimize the burden of diabetic complications due to renal involvement. Hence addition of microalbuminuria along with diabetic profile for medical checkup will help to assess microalbuminuria at frequent intervals.

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Normoalbuminuric diabetic kidney disease: a distinct entity?

Cited by 4 publications

References 26 publications

Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy

Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy

Relationship of angiotensin converting enzyme (I/D) polymorphism (rs4646994) and coronary heart disease among a male Iraqi population with type 2 diabetes mellitus

A study of microalbuminuria in patients with type 2 diabetes mellitus, visiting tertiary care center Sangli

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