Nonprocessed Adipose Tissue Graft in the Treatment of Peri-Implant Osseous Defects in the Rabbit's Tibiae: A Pilot Study

Zanicotti, Diogo Godoy; Matsubara, Fernanda Brugin; Zielak, João César; Giovanini, Allan Fernando; Urban, Cı́cero de Andrade; Deliberador, Tatiana Miranda

doi:10.1563/aaid-joi-d-11-00149

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…The adipose tissue seems to impede the bone formation around the implant. Contrary to Godoy Zanicotti et al (26), the results of the present study showed new bone formation in the treatment group (i.e., fragmented adipose tissue graft).…”

Section: Discussioncontrasting

confidence: 99%

“…In a pilot study with rabbit’s tibiae, Godoy Zanicotti et al (26) evaluated non-processed adipose tissue graft in the treatment of peri-implant osseous defects. According to the authors, the use of non-processed adipose tissue around surgically created peri-implant osseous defects interfered negatively with the bone formation (26).…”

Section: Discussionmentioning

confidence: 99%

“…According to the authors, the use of non-processed adipose tissue around surgically created peri-implant osseous defects interfered negatively with the bone formation (26). The adipose tissue seems to impede the bone formation around the implant.…”

Section: Discussionmentioning

confidence: 99%

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Fragmented adipose tissue graft for bone healing: Histological and histometric study in rabbits calvaria

Oliveira¹,

Giovanini²,

Abuabara³

et al. 2013

Med Oral

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Objective The adipose tissue represents an important reservoir of stem cells. There are few studies in the literature with which to histologically evaluate whether or not the adipose tissue graft is really a safe option to achieve bone repair. This study histologically analyzed the effect of fragmented autogenous adipose tissue grafts on bone healing in surgically created, critical-size defects (CSD) in a rabbit’s calvaria. Study design Forty-two New Zealand rabbits were used in this study. CSD that were 15 mm in diameter were created in the calvarium of each animal. The defects were randomly divided into two groups: in Group C (control), the defect was filled only by a blood clot and, in Group FAT (i.e., fragmented adipose tissue), the defect was filled with fragmented autogenous adipose tissue grafts. The groups were divided into subgroups (n = 7) for euthanasia at 7, 15, and 40 days after the procedure had been conducted. Histologic and histometric analyses were performed. Data were statistically analysed with ANOVA and Tukey’s tests (p < 0.05). Results The amount of bone formation did not show statistically significant differences seven days after the operation, which indicates that the groups had similar amounts of mineral deposition in the earlier period of the repair. Conversely, a significant of amount of bone matrix deposition was identified in the FAT group at 15 and 40 days following the operation, both on the border and in the body of the defect. Such an outcome was not found in the control group. Conclusion In this study, an autologous adipose tissue graft may be considered as likely biomaterial for bone regeneration, since it positively affected the amount of bone formation in surgically created CSD in the rabbits’ calvaria 40 days after the procedure had been performed. Further investigations with a longer time evaluation are warranted to determine the effectiveness of autologous adipose tissue graft in the bone healing. Key words:Adipose tissue, bone regeneration, rabbits, critical defects.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fragmented adipose tissue graft for bone healing: Histological and histometric study in rabbits calvaria

Oliveira¹,

Giovanini²,

Abuabara³

et al. 2013

Med Oral

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“…36 So, some studies have focused on the adipose tissue graft and whether it is a safe option to achieve bone repair or not. Zanicotti et al 37 evaluated the regenerating capacity of nonprocessed adipose tissue on bone around dental implants and reported that the use of adipose tissue around surgically created peri-implant osseous defects interferes with bone formation. In a study by Merikanto et al, 38 it was shown that rabbits with cranial bone defects can adversely affect osteogenesis when applied only to adipose tissue without isolation of stem cells.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Platelet-rich Plasma (PRP) and Fat Graft on Autologous Bone Grafting in a Randomized-controlled Experimental Skull Model

Gunes,

Oksuz,

Koseoglu

et al. 2024

Journal of Craniofacial Surgery

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Gold standard method for the treatment of critical-sized bone defects is the autogenous bone grafting procedure. A number of new and potentially useful adjuncts currently are being investigated to enhance the success of bone grafting. We propose to evaluate the effect of the most known and easily obtained 2 biological materials, fat graft and platelet-rich plasma (PRP), on bone graft healing. Twenty-seven New Zealand male rabbits were included in this randomized, controlled study. Two-sided 15-mm diameter bone defects were created in the parietal bones and the bones taken were replaced right-to-left and vice versa with 1 control group, 1 fat graft applied group, and the last one PRP applied group. Histologic evaluation and 3-dimensional maxillofacial computerized tomography were performed and bone density was calculated. In radiologic analysis, bone density was significantly different in the PRP group compared with the control and fat graft group in the 12th week (P<0.05). In histologic scoring analysis, the PRP group had a better score than the control and fat graft group, while the fat graft group was worse than the control group in the 6th week (P<0.05). The addition of PRP had a positive effect whereas fat graft had a negative effect on bone graft healing compared with the control group.

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Nonprocessed Adipose Tissue Graft in the Treatment of Peri-Implant Osseous Defects in the Rabbit's Tibiae: A Pilot Study

Cited by 2 publications

References 25 publications

Fragmented adipose tissue graft for bone healing: Histological and histometric study in rabbits calvaria

Fragmented adipose tissue graft for bone healing: Histological and histometric study in rabbits calvaria

Comparison of the Effect of Platelet-rich Plasma (PRP) and Fat Graft on Autologous Bone Grafting in a Randomized-controlled Experimental Skull Model

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