Noncytotoxic polycaprolactone-polyethyleneglycol-ε-poly(l-lysine) triblock copolymer synthesized and self-assembled as an antibacterial drug carrier

Abstract

A novel biodegradable and noncytotoxic polycaprolactone-polyethyleneglycol-3-poly(L-lysine) (PCL-PEG-EPL) triblock copolymer was synthesized via the combination of ring-opening polymerization and facile coupling reactions. The triblock copolymer can self-assemble into vesicles in aqueous solution, and PCL forms the vesicle membrane, whereas the PEG and EPL blocks constitute the vesicle coronas. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) had proved its vesicular structure.The excellent antibacterial ability of the 3-poly(L-lysine) makes the vesicles have good antibacterial activities towards both E. coli (Gram negative) and S. aureus (Gram positive), and the minimal inhibitory concentrations (MICs) were both 62.5 mg mL À1

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

“…This research aims to fabricate PCL brous mats containing b-carotene as bone tissue engineering scaffolds with the ability to self-differentiate MSCs to osteoblasts without using any osteogenic differential agent. Polycaprolactone (PCL) was chosen as a polymer with high mechanical strength, lack of toxicity and low cost [34][35][36] for fabricating scaffolds via an electrospinning process. First, the morphology and biocompatibility of the mats for bone tissue engineering were evaluated and then, their performance in simulating the appropriate environment for the differentiation of MSCs to osteoblasts was studied.…”

Polymeric Antimicrobial Food Packaging and Its Applications

“…In comparison with natural antimicrobial peptides, synthetic antimicrobial peptides have more stable properties. Synthetic antimicrobial peptides easily to copolymerize via the ring-opening polymerization of α-amino acid N -carboxyanhydrides (NCA) directly with polymers (such as PCL) to form film-forming materials [23,112,113].…”

Uniform, length-tunable antibacterial 1D diblock copolymer nanofibers

“…41,[43][44][45][46] Previous studies of antibacterial BCP nanoparticles have led to promising results for both nanospheres and vesicles. [47][48][49][50] More recently, Dove, O'Reilly, and coworkers employed CDSA to assemble diamond platelets composed of poly(L-lactide)block-poly(dimethylaminoethyl methacrylate) (PLLA-b-PDMAEMA). 25 A difference in antibacterial activity was observed between nanospheres and 2D platelets, with small platelets performing better than nanospheres and large platelets.…”