2012
DOI: 10.1089/gtmb.2012.0061
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No Association of Catechol-O-Methyltransferase Polymorphisms with Schizophrenia in the Han Chinese Population

Abstract: Aims: Genetics play a major role in the etiology of schizophrenia (SZ). Catechol-O-methyltransferase (COMT) is one of the promising candidate genes for SZ. A nonsynonymous single-nucleotide polymorphism (SNP), rs4680, causing a Valine (Val) to Methionine (Met) substitution, has been widely studied in relation to psychiatric phenotypes, including SZ, but with conflicting results. We conducted a two-stage study to examine the association of COMT polymorphisms with SZ in the Han Chinese population. Results: Assoc… Show more

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Cited by 8 publications
(7 citation statements)
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References 21 publications
(24 reference statements)
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“…In the study of genes that give the scenario susceptibility to schizophrenia, some genes were tested, and there were no satisfactory results, like PEA15 genes, ENTPD4, Genes GAS2L1 [120] and COMT [12]. The PEA15 gene is located at 1q21.1, the gene is ENTPD4 on 8p21.3 and GAS2L1 gene is in 22q12.…”
Section: Negative Resultsmentioning
confidence: 99%
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“…In the study of genes that give the scenario susceptibility to schizophrenia, some genes were tested, and there were no satisfactory results, like PEA15 genes, ENTPD4, Genes GAS2L1 [120] and COMT [12]. The PEA15 gene is located at 1q21.1, the gene is ENTPD4 on 8p21.3 and GAS2L1 gene is in 22q12.…”
Section: Negative Resultsmentioning
confidence: 99%
“…These three genes are homologous [120]. The COMT gene is located at 22q11.2, which is a region that has been implicated in linkage areas of SCZ [12] [121].…”
Section: Negative Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Several investigators have reported a significant association between the COMT polymorphism and schizophrenia (Sazci et al, 2004;Lafuente et al, 2008;Gupta et al, 2009;Hoenicka et al, 2010;Costas et al, 2011;Wan et al, 2011), while other studies have shown a lack of association between the COMT (Val 158 Met) polymorphism and schizophrenia (Karayiorgou et al, 1998;Okochi et al, 2009;Kong et al, 2011;Zhang et al, 2012). Moreover, the results of the studies on Caucasian and Asian ethnic groups have shown both inter-and intra-ethnic variations (Rosa et al, 2004;Gupta et al, 2009;Nieratschker et al, 2010;Wang et al, 2010).…”
mentioning
confidence: 99%