Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients

Al-Asmary, Saeed M.; Kadasah, Saeed; Arfin, Misbahul; Tariq, Mohd; Alasmari, Abdulrahman

doi:10.4238/2014.april.17.4

Cited by 9 publications

(3 citation statements)

References 41 publications

(49 reference statements)

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“…The results pertaining to COMT gene variant were similar to those of the studies done on Asian populations reported in Korea ( 27 ), Taiwan ( 28 ) and France ( 13 ). However, in other ethnic Asian populations, such as Saudi Arabia ( 31 ), India ( 32 ), China ( 30 ) and Turkey ( 29 ), a significant association has been reported between genotype and allotype frequencies in schizophrenia group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia

Yunaini¹,

Khairat²

2022

MJMS

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Background: Schizophrenia is a multifactorial disease in which genetic factors play a greater role than other factors. The genes of importance in schizophrenia patients are the genes that encode for neurotransmitters associated with low minor allele frequency (MAF) scores. This study was aimed to determine the association of genetic variations in catechol-O-methyl transferase (COMT), Ras association domain family member 1 (RASSF1) and glycoprotein M6A (GPM6A) with the risk of paranoid schizophrenia (PS) in patients admitted to Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia. Methods: Genotyping analysis through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR-amplification refractory mutation system (ARMS) was performed in 100 PS patients and 100 healthy controls. Chi-square and Fisher’s exact tests were used to compare the frequencies of genotype and allotype between the PS and control groups. Odds ratio (OR) with 95% confidence interval (95% CI) were calculated to determine the relative risk of PS with respect to genetic variations. Results: Polymorphism rs13142920 in GPM6A was associated with significantly elevated risk of PS (P = 0.020; OR = 1.60 [95% CI: 1.08, 2.39]). However, COMT rs4680 and RASSF1 rs2073499 polymorphisms were not significantly associated with PS. Conclusion: The GPM6A rs13142920 polymorphism holds great potential as a genetic marker in PS patients.

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Section: Discussionmentioning

confidence: 99%

Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia

Yunaini¹,

Khairat²

2022

MJMS

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“…(25) S-Al-Asmary, et al in 2014 on the Arab population. (26) Research conducted by EM Sutrisna, 2016 on Javanese, (27)…”

Section: Such Variations Could Affect the Biological Functionsmentioning

confidence: 99%

Association between Cathecol -O-Methyltransferase (COMT) Val 158 Met Polymorphisms and Psychosocial Stressors in Torajanese Schizophrenic Patients

Lisal T Sonny,

Tanra Andi Jayalangkara,

AndaSantiwati

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Objectives: TheTorajanese has a ritual tradition for the dead and marriage ceremonies from generation to generation on a large-scale; this is one of the cultural factor that influences the evolution of genetic adaptation. Increased incidence of schizophrenia annually is often associated with Cathecol-O-Methyltransferase (COMT) Val 158 Met polymorphisms as one of the genes causing schizophrenia. This study was aimed to determine the association between Cathecol -O-Methyltrnasferase Val 158 Met polymorphisms and psychosocial stressors with schizophrenia in Torajanese schizophrenia patients. Method:This was a quantitative study with a cross-sectional analytical description. There were 210 subjects divided equally into 3 groups, namely the Torajanese schizophrenia group with three subsequent generations (n = 70), normal Torajanese group (n = 70) and normal non-Torajanese group (n = 70). This study was conducted at Hasanuddin University Hospital and its network. PCR and RFLP examination were used for Cathecol-O-Methyltransferase (COMT) Val 158 Met polymorphism. Questionnaire was used to assess the psychosocial stressors.Result: There was a significant difference in the distribution of genotypes between the Torajanese schizophrenia group and the normal Torajanese group, between the normal Torajanese group and the the normal non-Torajanese group (p <0.05). There were 3 genotypes in Cathecol -O-Methyltransferase (COMT) Val 158 Met polymorphisms in Torajanese, namely Val/Val, Val/Met and Met/Met; and for the 140 subjects of the Torajanese, the amount of Val/Val genotypes was 104 (74.3 %) subjects, Val/Met genotype was 32 (22.9%) subjects and Met/Met genotype was 4 (2.9%) subjects. It was found that 66 (47.1%) subjects had psychosocial stressors and 74 (52.9%) subjects didn't have psychosocial stressor. Conclusion:There was a significant relationship between Cathecol -O-Methyltransferase (COMT) Val 158 Met polymorphisms and Torajanese schizophrenia group. There was a significant association between psychosocial stressors and Torajanese schizophrenia group. There was no significant difference in PANSS scores on the COMT Val 158 Met polymorphism genotypes.

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“…The Val158Met substitution is a functional polymorphism in which the Met allele has 3-4-fold reduced COMT activity resulting in lower levels of neurotransmitter degradation and higher levels of transmitter availability [ 26 ]. The ancestral Val allele has been reported in control populations at highest frequencies in Asians (69–80%) and lower frequencies in Caucasians (46–60%), North Africans (50–80%), and Arabs (44–50%) [ 27 – 30 ]. COMT is located in a region of chromosome 22 that was implicated in the pathogenesis of schizophrenia in early linkage analysis studies so many COMT studies have focused on its association with schizophrenia and related risk factors like stress and drug use [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth

et al. 2022

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Responses to early life adversity differ greatly across individuals. Elucidating which factors underlie this variation can help us better understand how to improve health trajectories. Here we used a case:control study of refugee and non-refugee youth, differentially exposed to war-related trauma, to investigate the effects of genetics and psychosocial environment on response to trauma. We investigated genetic variants in two genes (serotonin transporter, 5-HTT, and catechol-O-methyltransferase, COMT) that have been implicated in response to trauma. We collected buccal samples and survey data from 417 Syrian refugee and 306 Jordanian non-refugee youth who were enrolled in a randomized controlled trial to evaluate a mental health-focused intervention. Measures of lifetime trauma exposure, resilience, and six mental health and psychosocial stress outcomes were collected at three time points: baseline, ~13 weeks, and ~48 weeks. We used multilevel models to identify gene x environment (GxE) interactions and direct effects of the genetic variants in association with the six outcome measures over time. We did not identify any interactions with trauma exposure, but we did identify GxE interactions with both genes and resilience; 1) individuals with high expression (HE) variants of 5-HTTLPR and high levels of resilience had the lowest levels of perceived stress and 2) individuals homozygous for the Val variant of COMT with high levels of resilience showed stable levels of post-traumatic stress symptoms. We also identified a direct protective effect of 5-HTTLPR HE homozygotes on perceived insecurity. Our results point to novel interactions between the protective effects of genetic variants and resilience, lending support to ideas of differential susceptibility and altered stress reactivity in a cohort of war-affected adolescents.

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Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients

Cited by 9 publications

References 41 publications

Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia

Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia

Association between Cathecol -O-Methyltransferase (COMT) Val 158 Met Polymorphisms and Psychosocial Stressors in Torajanese Schizophrenic Patients

Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth

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