Association between COMT gene rs165599 SNP and schizophrenia: A meta‐analysis of case‐control studies

Abstract

BackgroundThere are many studies with different results that examine the association between Catechol‐O‐MethylTransferase (COMT) gene single‐nucleotide polymorphisms (SNPs) and schizophrenia. In this study, the aim was to conduct a meta‐analysis to achieve a pooled effect size of the association between COMT gene rs165599 SNP and schizophrenia.MethodsOdds ratio (OR) was used as an effect size to determine the association between schizophrenia and the SNP. The pooled ORs were achieved under four different genetic models. When the heterogeneity among studies was high the DerSimonian‐Laird random‐effects model, otherwise the Mantel‐Haenszel fixed‐effects model was used. Publication bias was evaluated by Egger's test.ResultsUnder different genetic models no statistically significant association was found between rs165599 SNP and schizophrenia by meta‐analyses consist of 20 independent studies. There was high heterogeneity among studies, for the possible reason the population differences, although the subgroup analyzes reduced the heterogeneity, no association was obtained. However, the sex‐specific estimation of the females showed that to be a G allele carrier is a risk factor for schizophrenia (OR = 1.366 [95% confidence interval = 1.094–1.706]) compared to AA homozygous.ConclusionThe COMT gene rs165599 SNP does not appear to be a single‐risk factor for schizophrenia.

Longitudinal study investigating the influence of COMT gene polymorphism on cortical thickness changes in Parkinson's disease over four years

“…A meta-analysis of 20 case–control studies examining the association between the COMT gene rs165599 SNP and schizophrenia revealed no significant correlation between rs165599 SNP and schizophrenia across diverse populations 35 .…”

The effects of catechol‐O‐methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta‐analysis

“…COMT activity closely depends on genotype, therefore, studies have focused on single nucleotide polymorphisms (SNP) in the COMT gene (Costas et al, 2011; González‐Castro et al, 2016; Gozukara Bag, 2018). In fact, SNPs located in locus 22q11.22–23 are the most studied genetic markers in schizophrenia to date.…”

“…In fact, SNPs located in locus 22q11.22–23 are the most studied genetic markers in schizophrenia to date. So far, COMT val108/158met (rs4680), rs165599, rs737865, and rs4633 polymorphisms have been identified in schizophrenia (Gozukara Bag, 2018; Okochi et al, 2009). The most studied polymorphism, val108/158met (rs4680), occurs when methionine is replaced by valine at codon 158 in the membrane‐bound isoform of COMT (MB‐COMT).…”

Avaliação de marcadores genéticos em uma coorte de indivíduos em alto risco para psicose Subclinical Symptoms Assessment and Prodromal Psychosis Program (SSAPP)

“…Para escolher os SNPs, usamos 2 métodos distintos. Primeiramente, selecionamos 20 SNPs candidatos, em 8 genes (COMT, DAO, DAOA, DISC1, DTNBP1, NRG1, DRD2, DRD1), que já haviam sido relatados em estudos prévios de associação a Esquizofrenia ou sintomas psicóticos, e que têm relação com as hipóteses dopaminérgica e glutamatérgica (67,77,(84)(85)(86)(87)(88)(89)(90)(91). Os 40 SNPs restantes, foram escolhidos entre os polimorfismos com associação mais forte, baseado no estudo de GWAS da International Schizophrenia Consortium case-control sample (70).…”