NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers

Bednarek, Elżbieta; Bocian, Wojciech; Michalska, Katarzyna

doi:10.1016/j.chroma.2008.04.008

Cited by 49 publications

(32 citation statements)

References 25 publications

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“…NMR and molecular modeling were performed to study the chiral recognition process occurring in the CE enantioseparation between linezolid and anionic singleisomer cyclodextrin-heptakis-(2,3-diacetyl-6-sulfato)--cyclodextrin (166). CE with -cyclodextrin as a chiral selector was used in the enantioseparation of racemic salsolinol, N-methylsalsolinol, and 1-benzyltetrahydroisoquinoline, and a computer modeling study of the inclusion complexes was reported (167).…”

Section: Capillary Electrophoresismentioning

confidence: 99%

Chiral Separations: Fundamental Review 2010

2010

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Section: Capillary Electrophoresismentioning

confidence: 99%

Chiral Separations: Fundamental Review 2010

2010

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“…Nevertheless, the molecular modeling studies may significantly contribute to the understanding of the nature of intermolecular forces responsible for guest–CD interactions, especially when used in combination with other instrumental techniques as ROESY and NMR. Thus, frequently a combination of chiral CE with molecular modeling and NMR experiments has been found to be the most reliable approach . Moreover, besides NMR and molecular modeling, other supporting techniques are also used from time to time, specifically MS and/or circular dichroism .…”

Section: Selected Aspects Related To Chiral Ce Based On Cdsmentioning

confidence: 99%

Application of cyclodextrins in chiral capillary electrophoresis

et al. 2014

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CE represents a very powerful separation tool in the area of chiral separations. CD-mediated chiral CE is a continuously flourishing technique within the frame of the electromigration methods. In this review, a brief overview of the synthetic procedures leading to modified CDs is provided first. Next, selected aspects related to the utilization of CDs in chiral CE are discussed specifically in the view of recently published data. Advantages of CDs and basic principles of chiral CE are remained. The topic of the determination of binding constants is touched. Particular attention is paid to the effort aiming at better understanding of the molecular level of the enantiorecognition between CDs and the analyte in the solution. Powerful approaches extensively utilized in this field are NMR, molecular modeling, and computer simulations. Then, a summary of applications of CDs in the CE enantioseparations is given, covering years 2008-2013. Finally, the general trend of modified CDs use in separation science is statistically evaluated.

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“…Upon optimizing the detector’s response (number of coil turns, frequency, and effective voltage), its feasibility and performance were demonstrated by analyzing inorganic ions (KCl and MgCl 2 ). Although not integrated, several other reports supported the advantages of correlating CE and NMR information [177–179]. As pointed in a recent review [180], due to the optimal premises of both techniques, further developments in CE-NMR are expected to open new research avenues in the near future.…”

Section: - Instrumentationmentioning

confidence: 99%

Recent developments in instrumentation for capillary electrophoresis and microchip‐capillary electrophoresis

2010

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Over the last years there has been an explosion in the number of developments and applications of capillary electrophoresis (CE) and microchip-CE. In part, this growth has been the direct consequence of recent developments in instrumentation associated with CE. This review, which is focused on contributions published in the last five years, is intended to complement the papers presented in this special issue dedicated to Instrumentation and to provide an overview on the general trend and some of the most remarkable developments published in the areas of high voltage power supplies, detectors, auxiliary components, and compact systems. It also includes few examples of alternative uses of and modifications to traditional CE instruments.

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NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers

Cited by 49 publications

References 25 publications

Chiral Separations: Fundamental Review 2010

Chiral Separations: Fundamental Review 2010

Application of cyclodextrins in chiral capillary electrophoresis

Recent developments in instrumentation for capillary electrophoresis and microchip‐capillary electrophoresis

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