NIR-laser-triggered gadolinium-doped carbon dots for magnetic resonance imaging, drug delivery and combined photothermal chemotherapy for triple negative breast cancer

Jiang, Qunjiao; Liu, Li; Li, Qiuying; Cao, Yi; Chen, Dong; Du, Qi-Shi; Yang, Xiaobo; Huang, Dongping; Pei, Renjun; Chen, Xing; Huang, Guohong

doi:10.1186/s12951-021-00811-w

Cited by 51 publications

(37 citation statements)

References 51 publications

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“…In addition, CNDs are fluorescent nanotools considered as an optimal candidate for cancer diagnosis [ 96 ]. Different researchers exploited properly engineered CNDs in combination with other contrast agents, such as gadolinium [ 97 ] or Fe 3+ [ 98 ], to improve their cyto-biocompatibility, to inhibit leakage or, in the case of conjugation with Fe 3+ , to improve discrimination between normal and cancerous cells [ 99 ].…”

Section: Therapeutic Carbon Dots In Pediatric Glioma Diagnosis and Treatmentmentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

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Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood–brain barrier. In this review we will discuss the developments of nanoparticle-based strategies as novel precision nanomedicine tools for diagnosis and therapy in pediatric brain cancers, with a particular focus on targeting strategies to overcome the main physiological obstacles that are represented by blood–brain barrier.

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Section: Therapeutic Carbon Dots In Pediatric Glioma Diagnosis and Treatmentmentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

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“…CNDs have also demonstrated potential in photothermal therapy [35,36,[63][64][65][66][67][68]. This process usually involves using a NIR laser to illuminate a tumor.…”

Section: Photothermal Therapymentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

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Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

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“…Fluorescent CQDs can be used as imaging probes. Metals like Gadolinium have been used in combination with CQDs, which not only reduce their toxicity to organs but also prevent their leakage ( Huang et al, 2020 ; Jiang et al, 2021 ). Many fluorescent sensors for Fe 3+ detection are being developed nowadays, most of them are based on CQDs.…”

Section: Nanotechnology For Cancer Diagnosismentioning

confidence: 99%

Carbon Based Nanodots in Early Diagnosis of Cancer

et al. 2021

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Detection of cancer at an early stage is one of the principal factors associated with successful treatment outcome. However, current diagnostic methods are not capable of making sensitive and robust cancer diagnosis. Nanotechnology based products exhibit unique physical, optical and electrical properties that can be useful in diagnosis. These nanotech-enabled diagnostic representatives have proved to be generally more capable and consistent; as they selectively accumulated in the tumor site due to their miniscule size. This article rotates around the conventional imaging techniques, the use of carbon based nanodots viz Carbon Quantum Dots (CQDs), Graphene Quantum Dots (GQDs), Nanodiamonds, Fullerene, and Carbon Nanotubes that have been synthesized in recent years, along with the discovery of a wide range of biomarkers to identify cancer at early stage. Early detection of cancer using nanoconstructs is anticipated to be a distinct reality in the coming years.

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NIR-laser-triggered gadolinium-doped carbon dots for magnetic resonance imaging, drug delivery and combined photothermal chemotherapy for triple negative breast cancer

Cited by 51 publications

References 51 publications

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Carbon Based Nanodots in Early Diagnosis of Cancer

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