Carbon Based Nanodots in Early Diagnosis of Cancer

Singh, Gurpal; Kaur, Harinder; Sharma, Akanksha; Singh, J. S.; Alajangi, Hema Kumari; Kumar, Santosh; Singla, Neha; Kaur, Indu Pal; Barnwal, Ravi Pratap

doi:10.3389/fchem.2021.669169

Cited by 12 publications

(6 citation statements)

References 141 publications

(119 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CQDs have contributed to improved diagnostics and treatments for various medical conditions. In neurodegenerative diseases, CQDs have been employed for early-stage diagnosis and monitoring of disease progression [85]. Moreover, CQDs have shown potential in infectious disease management, including bacterial and viral infections, by providing real-time information on disease location and response to treatment [86,87].…”

Section: Improved Diagnostics and Treatmentsmentioning

confidence: 99%

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

Parvin,

Kumar,

Joo

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Carbon-based nanomaterials, such as carbon quantum dots (CQDs) and carbon 2D nanosheets (graphene, graphene oxide, and graphdiyne), have shown remarkable potential in various biological applications. CQDs offer tunable photoluminescence and excellent biocompatibility, making them suitable for bioimaging, drug delivery, biosensing, and photodynamic therapy. Additionally, CQDs’ unique properties enable bioimaging-guided therapy and targeted imaging of biomolecules. On the other hand, carbon 2D nanosheets exhibit exceptional physicochemical attributes, with graphene excelling in biosensing and bioimaging, also in drug delivery and antimicrobial applications, and graphdiyne in tissue engineering. Their properties, such as tunable porosity and high surface area, contribute to controlled drug release and enhanced tissue regeneration. However, challenges, including long-term biocompatibility and large-scale synthesis, necessitate further research. Potential future directions encompass theranostics, immunomodulation, neural interfaces, bioelectronic medicine, and expanding bioimaging capabilities. In summary, both CQDs and carbon 2D nanosheets hold promise to revolutionize biomedical sciences, offering innovative solutions and improved therapies in diverse biological contexts. Addressing current challenges will unlock their full potential and can shape the future of medicine and biotechnology.

show abstract

Section: Improved Diagnostics and Treatmentsmentioning

confidence: 99%

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

Parvin,

Kumar,

Joo

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Carbon nitride dots (CNDs) are small biocompatible, non-toxic nanoparticles with the ability to selectively target cancer cells [ 95 ]. In addition, CNDs are fluorescent nanotools considered as an optimal candidate for cancer diagnosis [ 96 ]. Different researchers exploited properly engineered CNDs in combination with other contrast agents, such as gadolinium [ 97 ] or Fe 3+ [ 98 ], to improve their cyto-biocompatibility, to inhibit leakage or, in the case of conjugation with Fe 3+ , to improve discrimination between normal and cancerous cells [ 99 ].…”

Section: Therapeutic Carbon Dots In Pediatric Glioma Diagnosis and Treatmentmentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

View full text Add to dashboard Cite

Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood–brain barrier. In this review we will discuss the developments of nanoparticle-based strategies as novel precision nanomedicine tools for diagnosis and therapy in pediatric brain cancers, with a particular focus on targeting strategies to overcome the main physiological obstacles that are represented by blood–brain barrier.

show abstract

“…In terms of hydrophilicity, biocompatibility, simplicity of manufacture, and toxicity, fluorescent CQDs outperform organic dyes. CQDs are hence regarded as excellent for cancer detection (Singh et al, 2021). Fluorescent CQDs have the potential to be employed as imaging probes.…”

Section: Carbon Dots In Cancer Diagnosis and Therapymentioning

confidence: 99%

Applications of Carbon Quantum Dots in Cancer Detection and Therapy

Kaur

Srivastava

Aggarwal

et al. 2022

Advances in Transdisciplinary Engineering

View full text Add to dashboard Cite

Cancer is a global concern and a major cause of early deaths as well as poor lifestyles. One of the prime research areas of cancer includes nanotechnology and its applications. Many nanomaterials like carbon nanotubes, nanoshells, nanorod arrays, polymer dots, quantum dots, etc have been highlighted owing to their excellent characteristics aiding in cancer diagnostics and therapeutics. In this paper, the authors aim to highlight the application of one of such nanostructures, i.e, Carbon quantum dots (CQDs). These nanoparticles have seen widespread application in cancer due to their special optical characteristics, high quantum yield as well as good electrical properties. They also possess excellent photostability. The past few decades have seen their application in diagnostic devices, assays, biosensors, bioimaging, drug delivery, and other therapeutic applications as well. The review summarizes its remarkable characteristics and recent trends in cancer diagnostics and therapeutics. The outcome of our literature review highlights that CQDs are able to detect specific types of cancer and differentiate between normal and malignant cells, hence, making cancer diagnosis more efficient. Similarly, in cancer therapy, the excellent photoluminescence property of CQDs has been well exploited in drug delivery.

show abstract

Carbon Based Nanodots in Early Diagnosis of Cancer

Cited by 12 publications

References 141 publications

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

Applications of Carbon Quantum Dots in Cancer Detection and Therapy

Contact Info

Product

Resources

About