New perspectives on radicular cysts: do they heal?

Nair, Prashant

doi:10.1046/j.1365-2591.1998.00146.x

Cited by 252 publications

(239 citation statements)

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“…Chronic inflammatory infiltrate, multinucleated giant cells and neutrophils were also observed in the cysts. These features are comparable to those described previously (1,5).…”

Section: Discussionsupporting

confidence: 91%

“…by stratified squamous epithelium exhibiting spongiosis and/or exocytosis and are delimited by a fibrous wall containing a predominantly chronic inflammatory infiltrate (1). However, little has been described about the histopathological features and variations of RCs diagnosed in Brazilian individuals specifically.…”

Section: Histopathological Study Of Radicular Cysts Diagnosed In a Brmentioning

confidence: 99%

“…They are related to extensive caries lesions, pulp necrosis and infection of the root canal (1). RCs arise to control the infection as the lowintensity chronic stimulus triggered by bacterias and their products provides conditions to the organism, confining the aggression to the periapical region.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological study of radicular cysts diagnosed in a Brazilian population

et al. 2011

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The aim of this study was to investigate the histopathological features of radicular cysts (RCs) diagnosed in a Brazilian population. Seventy-three cases of RCs, from a total of 1480 biopsies diagnosed between 2001 and 2008 at the Laboratory of Oral Surgical Pathology of the Dental School of the Federal University of Bahia were investigated regarding their histopathological features. Morphological results showed that exocytosis (n=50), spongiosis (n=40), acanthosis (n=28), atrophic epithelium (n=27) and apoptotic bodies (n=21) were the most common findings. Other morphological findings included: foamy macrophages (n=10), Russell's bodies (n=7), cholesterol crystals (n=7) and glandular-like odontogenic epithelial rests (n=1). Evidence of exogenous material was seen in 16 samples. It was concluded that the clinical and histopathological findings observed in Brazilian patients were comparable with those described for other populations.

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“…Chronic inflammatory infiltrate, multinucleated giant cells and neutrophils were also observed in the cysts. These features are comparable to those described previously (1,5).…”

Section: Discussionsupporting

confidence: 91%

Section: Histopathological Study Of Radicular Cysts Diagnosed In a Brmentioning

confidence: 99%

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Histopathological study of radicular cysts diagnosed in a Brazilian population

et al. 2011

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“…Dentre estes fatores, podem-se citar citocinas inflamatórias, como as interleucinas 1 e 6 (IL-1a, IL-1b, IL-6), e o Fator de Necrose Tumoral (TNF) 3 . Devido a isso, a primeira linha de tratamento para os CR é o tratamento endodôntico, para eliminar a inflamação presente e permitir a involução da lesão [4][5][6][7] . No entanto, nem sempre esse tratamento é suficiente e o cisto pode continuar a crescer, necessitando de tratamento cirúrgico, o que ocorre na maioria dos casos de CRe que continuam a crescer mesmo na ausência do fator etiológico (canal radicular infectado) 6,8 .…”

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Avaliação do metabolismo epitelial em cistos radiculares pela técnica de AgNORS

Cavalli

Modolo

Rivero

2014

Rev. odontol. UNESP

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ResumoIntrodução: A formação do Cisto Radicular (CR) está associada à proliferação dos restos epiteliais de Malassez por estímulos inflamatórios, provenientes da proliferação bacteriana do canal radicular de um dente não vital. Quando o dente é removido, esse cisto passa a ser denominado Cisto Residual (CRe). O tratamento de escolha para o CR é endodôntico, com o objetivo de eliminar a inflamação presente no periápice. No entanto, em alguns casos, o cisto pode continuar a crescer, necessitando de tratamento cirúrgico, o que ocorre na maioria dos casos de CRe. Objetivo: Avaliar o metabolismo do epitélio de revestimento de CR e CRe, utilizando a quantificação das AgNORs, e verificar a influência da presença de inflamação sobre o crescimento desses cistos. Material e método: Vinte casos de CR e dez de CRe foram submetidos à técnica de AgNOR. A análise quantitativa das NORs foi realizada utilizando-se o software 'Contando células' . O teste estatístico pós-hock de Newman-keuls foi realizado para a comparação do número médio de AgNORs entre CR e CRe, e entre áreas inflamadas e não inflamadas. Resultado: Diferença estatisticamente significante (p=0,0094) foi observada entre áreas inflamadas (1,86±0,26) e não inflamadas (1,65±0,20). Na comparação entre CR (1,81±0,28) e CRe (1,73±0,16), não houve diferença estatisticamente significante (p=0,37). Conclusão: A inflamação interfere no metabolismo epitelial de CR e CRe, o que reflete a ação de fatores de crescimento na proliferação do epitélio, contribuindo para o crescimento do cisto, independentemente da presença do fator etiológico associado com a origem da lesão.Descritores: Cisto radicular; cisto residual; inflamação; AgNOR. AbstractIntroduction: Radicular Cyst (RC) development is associated with the activation and proliferation of epithelial rests of Malassez. This occurs due to inflammatory stimuli resulting from bacteria proliferation in the root canal of a non-vital tooth. When the tooth is removed, the cyst becomes known as Residual Cyst (ReC). The RC common treatment is the endodontic therapy, with the aim of eliminating the inflammation in the periapical region. Nonetheless, this treatment is not always effective and the cyst may continue to grow, what happens in most cases of ReC. Objective: To evaluate the metabolism of the RC and ReC epithelial lining through the technique of AgNOR quantification and of the influence of the presence of inflammation in the growth of these cysts. Material and method: 20 cases of RC and 10 of ReC, were processed by the AgNOR technique. The AgNOR quantitative analysis was performed using the "Counting cells" software. The statistical post-hock Newman-Keuls test was applied to compare the RC and ReC mean number of AgNORs in inflamed and non-inflamed areas. Result: Statistically significant difference (p=0.0094) was observed between inflamed (1.86±0.26) and non-inflamed (1.65±0.20) areas. No statistically significant difference (p=0.37) was observed in the comparison between RC (1.81±0.28) and ReC (1.73±0.16). Conclusion: Inflammat...

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“…About 52% of all apical periodontitis contain proliferating epithelium, (1) widely held to be derived from the cell rests of Malassez. (2,3) Although the reported prevalence of cysts among apical periodontitis lesions varies from 6 to 55% (4) investigations based on meticulous serial sectioning and strict histopathological criteria (1,5,6) show that the actual prevalence of the cysts is well below 20%.…”

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confidence: 99%