Experimental evidence supports the abscess theory of development of radicular cysts

Nair, Prashant; Sundqvist, Göran; Sjögren, U.

doi:10.1016/j.tripleo.2008.04.009

Cited by 35 publications

(39 citation statements)

References 25 publications

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“…A recent study in an animal experiment reconfirms that cysts similar to apical cysts are formed from abscess lesions induced by bacterial infection (12). Any disease caused by infection, including apical cysts (pocket and true), should be able to heal if the causative irritant/irritants are removed or eliminated, unless the irritant/irritants are neoplasm-inducing agents or carcinogens.…”

Section: Regression Of Inflammatory Apical True Cysts After Nonsurgicmentioning

confidence: 99%

“…Several theories have been proposed concerning the formation of inflammatory apical cysts (3,(10)(11)(12). Regardless of how apical cysts are formed, an apical cyst (pocket and true) is a pathologic cavity completely lined by nonkeratinized stratified squamous epithelium of variable thickness in a 3-dimensional structure in an apical periodontitis lesion (Figs.…”

Section: Pathogenesis Histology and Biology Of Inflammatory Apical mentioning

confidence: 99%

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Nonsurgical Root Canal Therapy of Large Cyst-like Inflammatory Periapical Lesions and Inflammatory Apical Cysts

Lin

Ricucci²,

Lin

et al. 2009

Journal of Endodontics

127

124

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Section: Regression Of Inflammatory Apical True Cysts After Nonsurgicmentioning

confidence: 99%

Section: Pathogenesis Histology and Biology Of Inflammatory Apical mentioning

confidence: 99%

Nonsurgical Root Canal Therapy of Large Cyst-like Inflammatory Periapical Lesions and Inflammatory Apical Cysts

Lin

Ricucci²,

Lin

et al. 2009

Journal of Endodontics

127

124

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“…2 Cystic transformation occurs owing to inflammatory stimulation of the epithelial rests of Malassez in the periodontal ligament, secondary to a root canal infection, in which the bacteria and their products, that were previously confined to the dental pulp, go beyond the root canal system and reach the periapical tissues. 1,3 Periapical cyst formation seems to be induced by an acute inflammatory reaction, 4 although mononuclear cells are commonly found in the inflammatory infiltrate. 5 T-and B-lymphocytes and macrophages constitute most of the inflammatory cells involved.…”

Section: Introductionmentioning

confidence: 99%

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

et al. 2013

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The aim of this study was to evaluate the prevalence of periapical cysts, identify their clinical and microscopic features and correlate their microscopic features with the inflammatory infiltrate present in the lesion site. A total of 214 cases were collected over a 10-year period. Clinical data, including gender, age, race, symptoms and location of the lesion, were recorded. Two independent examiners with no prior knowledge of the patients' clinical data conducted the microscopic evaluations. Statistical analyses were performed using Fisher's or chi-square tests at a 5% level of significance. The results showed that periapical cysts were more prevalent in white women, with a mean age of 35 years, and in the anterosuperior region. The majority of the lesions were lined by atrophic cystic epithelium, which was associated with moderate inflammatory infiltrate in the cystic capsule (p < 0.01), with a diffuse localization pattern (p = 0.03) and absence of neutrophils (p = 0.01). Our findings suggest that periapical cysts lined by atrophic epithelium are related to the presence of moderate mononuclear inflammatory infiltrate.

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“…[19] He pointed out two distinct categories of radicular cysts, namely those containing cavities completely enclosed in epithelial lining (true cysts) and those containing epithelium-lined cavities that are open to the root canals (bay/pocket cysts). [17192021] It is also stated that bay cysts tend to response to nonsurgical endodontic intervention, while those few cysts categorized as true, have to be surgically removed. [1719] Strong evidences suggest that subsequent to removal of etiologic factors, immunological system contributes to the breakdown of epithelial cyst linings.…”

Section: Discussionmentioning

confidence: 99%

Nonsurgical management of an extensive endodontic lesion in an orthodontic patient by calcium-enriched mixture apical plug

Asgary¹,

Fazlyab

2014

Contemp Clin Dent

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Periapical lesion is a general term used to describe the periapical inflammatory process that occurs in response to the invasion of micro-organisms in the root canal system as well as inflamed vital pulp. This phenomenon necessitates endodontic intervention and if the necrosis has occurred prior to tooth maturation, wide patency of the apical foramen requires some treatment modalities such as apexification or apical plug. Orthodontic treatment, on the other hand, is cautiously done for previously traumatized teeth due to increased risk for necrosis of the compromised tooth. This article tends to review the successful treatment process with calcium-enriched mixture (CEM) cement apical plug for an immature previously traumatized incisor tooth with an extensive periapical lesion, which was under orthodontic treatment as well.

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Experimental evidence supports the abscess theory of development of radicular cysts

Cited by 35 publications

References 25 publications

Nonsurgical Root Canal Therapy of Large Cyst-like Inflammatory Periapical Lesions and Inflammatory Apical Cysts

Nonsurgical Root Canal Therapy of Large Cyst-like Inflammatory Periapical Lesions and Inflammatory Apical Cysts

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

Nonsurgical management of an extensive endodontic lesion in an orthodontic patient by calcium-enriched mixture apical plug

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