New chelate-forming polymer microspheres carrying dyes as chelators for iron overload

Abstract

Dye-incorporated [poly(EGDMA-HEMA)] microspheres were investigated as a new chelate-forming polymer for iron overload. Poly(EGDMA-HEMA) microspheres, in the size range of 150-200 microm, were produced by a modified suspension polymerization of EGDMA and HEMA. The reactive dye-ligands (i.e. Cibacron Blue F3GA, Alkali Blue 6B and Congo Red) were covalently incorporated to the microspheres. The maximum dye incorporations were 16.5 micromol Cibacron Blue F3GA g(-1), 23.7 micromol Alkali Blue 6B g(-1), and 14.5 micromol Congo Red g(-1). The maximum Fe(III) adsorptions on the dye-incorporated microspheres from aqueous solutions containing different amounts of Fe(III) ions were 51.0, 37.3, and 25.1 mg g(-1) for the Cibacron Blue F3GA, Alkali Blue 6B, and Congo Red carrying microspheres, respectively. The maximum Fe(III) adsorptions were observed at pH 4.0 in all cases. Fe(III) removal from human plasma was also investigated. The maximum adsorption capacities of Fe(III) ions from human plasma for Cibacron Blue F3GA, Alkali Blue 6B, and Congo Red, were of 12.0, 7.5, and 3.8 mg g(-1) polymer, respectively. It was observed that Fe(III) could be repeatedly adsorbed and desorbed without significant loss in adsorption capacity.

An Ion-Imprinted Monolith for in Vitro Removal of Iron out of Human Plasma with Beta Thalassemia

“…However, desferrioxamine mesylate is known to have some drawbacks in its application due primarely to ocular, auditary, and renal disturbances, and it becomes highly toxic at high doses or over prolonged periods of time. As an alternative to the adverse effects soluble iron chelators such as desferal, the attachment of iron chelating ligands including dye and protein molecules have been studied. , Compared to the soluble iron chelators, the iron chelating resins are thought to have some advantages in terms of stability, reusability, and minimal damage to biomolecules. Developing an efficient iron chelating system for the treatment of the patients with chronic iron overload usually involves the preparation of suitable and effective adsorbents to excrete the iron in the body.…”

Polymer−Clay Nanocomposite Iron Traps Based on Intersurface Ion-Imprinting

“…Recently, one of the most promising techniques for blood detoxification is extracorporeal affinity adsorption. So far, only a few affinity adsorbents were reported in literature. − However, selectivity still remains a great problem in these systems.…”

Catalytic wet oxidation of reactive dyes in water

“…Although there were several other technologies available for the removal of color and COD from dyehouse effluents such as biodegradation [4], sorption [5][6][7], electrochemical and oxidative degradation [8][9][10][11][12][13][14], wet air oxidation was a very attractive and useful technique for treatment of dyehouse effluents [15][16][17][18][19][20]. Wet air oxidation is a liquid phase oxidation of organic materials in water with oxygen (the main source of oxygen is generally air) without catalyst.…”

“…Although the use of catalyst makes the reaction conditions milder than uncatalyzed wet oxidation, the catalytic wet oxidation process still requires high temperature (higher than 150°C) and high pressure (1)(2)(3)(4)(5). This severe operating condition can lead to high installation costs, and thereby practical applications of this process are limited.…”