Neutrophils With Ring‐shaped Nuclei in Human Chagas' Disease

Cabral, H. R. A.

doi:10.1111/j.1365-2141.1987.tb02309.x

Cited by 5 publications

(9 citation statements)

References 6 publications

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“…One of the first studies performed in patients to investigate this relationship verified the presence of peripheral blood neutrophils with altered nucleus morphology from a conventional multi‐lobulated form to a ring shape. It is interesting that this morphology is also found in healthy individuals, but in a smaller amount than in patients with CD . This was undoubtedly strong evidence that neutrophils have a role in CD, opening doors for further research.…”

Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 88%

“…It is interesting that this morphology is also found in healthy individuals, but in a smaller amount than in patients with CD. 24 This was undoubtedly strong evidence that neutrophils have a role in CD, opening doors for further research.…”

Section: Evidence Of Involvement Of Neutrophils In the Pathology Ofmentioning

confidence: 97%

“…Since this last characteristic is common to immature neutrophils, it is assumed that components secreted by tumours, and possibly by inflammation caused by an infectious agent, could cause premature release of neutrophils from bone marrow . In CD, neutrophils with ring‐shaped nucleus have been reported since the 1980 s in the peripheral blood of patients . Recently, Rodríguez and collaborators showed a higher number of neutrophils with ring nuclei in Chagas positive serology, in 2‐hour cultures, than in blood cells of healthy individuals.…”

Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 99%

“…72,73 In CD, neutrophils with ring-shaped nucleus have been reported since the 1980 s in the peripheral blood of patients. 24 Recently, Rodríguez and collaborators showed a higher number of neutrophils with ring nuclei in Chagas positive serology, in 2-hour cultures, than in blood cells of healthy individuals. They also observed NETs in neutrophils with ring nuclei.…”

Section: Production Of Cytokines and Inflammatory Mediators: Regulatimentioning

confidence: 99%

“…Nevertheless, records in the scientific literature show that the period between the late 1970 s and the 1980 s was an opportune time to aggregate information regarding the relationship between neutrophils and CD . At this time, several independent research groups began to investigate whether there was any contribution of these cells to the immunopathogenesis of the disease.…”

Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 99%

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Involvement of neutrophils in Chagas disease pathology

Andrade

Almeida

Souza

et al. 2018

Parasite Immunology

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Chagas disease (CD) is a public health problem in Latin America. The acute phase presents nonspecific symptoms and most patients recover from acute parasitemia and undergo a prolonged asymptomatic phase. Several years later, about 30% of infected individuals develop chronic cardiopathy with progressive cardiomegaly, arrhythmia, thromboembolic events and heart failure. These symptoms suggest a persistent association with the presence of inflammatory infiltrate and tissue, and cellular destruction in the heart muscle. Nevertheless, few research studies have attempted to understand the role of inflammatory cells, such as neutrophils, in establishing the pathology and progression of CD. Only recently have some studies been performed with this intention. Despite this effort, the role of neutrophils in CD is still considered controversial. This review discusses the morphological and functional characteristics of neutrophils that describes their participation in the establishment and progression of Trypanosoma cruzi infection, through the development of its effector functions, such as release of lithic components, production of oxidative agents and release of inflammatory mediators capable of modulating the host immune response.

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Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 88%

Section: Evidence Of Involvement Of Neutrophils In the Pathology Ofmentioning

confidence: 97%

Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 99%

Section: Production Of Cytokines and Inflammatory Mediators: Regulatimentioning

confidence: 99%

Section: How Do Neutrophils Participate In the Immunopathogenesis Of mentioning

confidence: 99%

See 3 more Smart Citations

Involvement of neutrophils in Chagas disease pathology

Andrade

Almeida

Souza

et al. 2018

Parasite Immunology

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Ring‐shaped nuclei in human neutrophilic leukocytes of healthy individuals: Evidence of their occurrence and characteristics

Cabral

Robert

1989

American J Hematol

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In our previous work we found the presence of ring-shaped nuclei in circulating neutrophils of healthy individuals whose nuclei were stained only by means of the Feulgen reaction [1]. In our present work, we performed another study on the blood of 52 healthy human donors and stained their blood films with hematoxylin. In all cases, ring-shaped nuclei were revealed. In this series, the number of this type of nuclei was high: 15.61% +/- SD 7.18%. The ring nuclei of healthy humans had thin segments, such as we have previously found by means of Feulgen method.

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The mechanism of granulocyte nuclear shape determination: possible involvement of the centrosome

Olins

2005

European Journal of Cell Biology

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Neutrophils With Ring‐shaped Nuclei in Human Chagas' Disease

Cited by 5 publications

References 6 publications

Involvement of neutrophils in Chagas disease pathology

Involvement of neutrophils in Chagas disease pathology

Ring‐shaped nuclei in human neutrophilic leukocytes of healthy individuals: Evidence of their occurrence and characteristics

The mechanism of granulocyte nuclear shape determination: possible involvement of the centrosome

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