Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Biomarkers of Primary Open-Angle Glaucoma

Özgönül, Cem; Sertoğlu, Erdim; Mumcuoğlu, Tarkan; Küçükevcilioğlu, Murat

doi:10.1097/ijg.0000000000000392

Cited by 48 publications

(61 citation statements)

References 23 publications

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“…However, we have found only one study reporting the ROC analysis of a blood-based biomarker, which revealed that the AUC indicating the ability of the neutrophil-to-lymphocyte ratio to distinguish patients with POAG from controls was 0.651, with a sensitivity of 65% and a specificity of 65%. 44 In our study, we found that hsa-miR-210-3p is more effective in differentiating between POAG patients and matched controls, with an AUC of 0.846 (sensitivity: 84.6%; specificity: 80.8%) and 0.813 (sensitivity: 84.8%; specificity: 69.7%) in the screening and validation sets, respectively. The methodology used in our study is also unsurpassed in the POAG biomarker field.…”

Section: Discussionmentioning

confidence: 49%

Discovery and Validation of Circulating Hsa-miR-210-3p as a Potential Biomarker for Primary Open-Angle Glaucoma

Liu

Wang

Chen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Citation: Liu Y, Wang Y, Chen Y, et al. Discovery and validation of circulating hsa-miR-210-3p as a potential biomarker for primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2019;60:2925-2934. https://doi.org/ 10.1167/iovs.19-26663PURPOSE. Blood-based examination tools for glaucoma diagnosis in clinical practice, which can be useful for screening patients when traditional ophthalmic examinations cannot be utilized, are not available thus far. This study aimed to identify circulating microRNAs (miRNAs) associated with primary open-angle glaucoma (POAG) and explore their utility as diagnostic markers. METHODS.A total of 136 POAG patients and controls were enrolled. Next-generation RNA sequencing was used to explore the expression profile of circulating miRNAs in the sequencing set, and potential miRNAs from independent samples in both the screening and validation sets were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Receiver operating characteristic (ROC) analysis was used to evaluate the ability of certain miRNAs to distinguish POAG patients from control subjects. RESULTS.Using sequencing and qRT-PCR, hsa-miR-210-3p was found to be elevated in POAG patients in all sets. ROC analysis of the screening and validation sets revealed that hsa-miR-210-3p differentiated between POAG patients and matched controls with an area under the curve (AUC) of 0.846 (sensitivity: 84.6%; specificity: 80.8%) and 0.813 (sensitivity: 84.8%; specificity: 69.7%), respectively. In case of all nonsequencing participants, analysis revealed that hsa-miR-210-3p differentiated between severe POAG patients and controls with an AUC of 0.880 (sensitivity: 85.4%; specificity: 85.7%). In addition, the expression of hsa-miR-210-3p was associated with visual field defects of jmean deviationj (b ¼ 0.237; P ¼ 0.022) and average retinal nerve fiber layer thickness (b ¼ À5.792; P ¼ 0.014). CONCLUSIONS.Circulating hsa-miR-210-3p may serve as a potential diagnostic marker for POAG (especially for severe POAG patients).

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Section: Discussionmentioning

confidence: 49%

Discovery and Validation of Circulating Hsa-miR-210-3p as a Potential Biomarker for Primary Open-Angle Glaucoma

Liu

Wang

Chen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…[11] Oküler hastalıklar sistemik inflamasyondan ziyade lokal bir inflamatuar yanıta neden olmasına rağmen NLO'nun yaşa bağlı makular dejenerasyon, retinal ven tıkanıklığı, non-arteritik anterior iskemik optik nöropati, vernal keratokonjonktivit, kuru göz ve primer açık açılı glokom gibi çeşitli göz hastalıklarında ilişkili olduğu saptanmış-tır. [25][26][27][28][29][30][31] NLO'nun lokal inflamatuar hastalıklarda anlamlı olabilmesi için sistemik kan parametrelerinde değişiklik yapması gerekir. TO'deki inflamasyon aslında sistemik inflamasyonun bir sonucudur ve kan parametrelerini değiştirebilir.…”

Section: Discussionunclassified

The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

et al. 2018

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“…Subsequently, the second study assessed the levels of NLR in patients with pseudoexfoliation syndrome (PEX), pseudoexfoliation glaucoma (PXG) and healthy controls. NLR was found to be higher in both, PEX and PXG groups; therefore, NLR may be useful for predicting the prognosis of PEX patients and progression to PXG (26).…”

Section: Discussionmentioning

confidence: 99%

“…Two consecutive researches about glaucoma and NLR were reported more recently (25,26). In the fi rst study, the authors evaluated the NLR levels in patients with primary open-angle glaucoma and they found a signifi cant difference in NLR levels between POAG and control groups (25).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy

Çelik¹

2017

BLL

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PURPOSE: To evaluate the neutrophil-to-lymphocyte ratio (NLR) levels to predict the severity of infl ammation in thyroid ophthalmopathy (TO). METHODS: Fifty-six patients with TO and 40 healthy subjects were included in this study. TO patients were divided into two groups according to clinical activity score (CAS). Group 1 included 24 active TO patients and Group 2 included 32 inactive TO patients. The thyroid status, white blood cell (WBC), neutrophil, and lymphocyte counts were performed. NLR was calculated by dividing the neutrophil count by the lymphocyte count. RESULTS: The mean age was 53.6 ± 5.4 in active TO group, 54.2 ± 5.6 in inactive TO group, and 52.7 ± 5.2 in the control group. The WBC, neutrophil, lymphocyte and NLR levels were higher in patients with TO than in the control group (p < 0.05). A signifi cant difference in NLR was found between the inactive and active TO groups (p < 0.05). CONCLUSION: NLR values were found to be higher in patients with TO than in controls. NLRvalues were also found higher in active TO patients than in inactive TO patients (Tab. 3, Ref. 26). Text in PDF www.elis.sk.

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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Biomarkers of Primary Open-Angle Glaucoma

Abstract: Our study for the first time provides evidence that NLR and PLR may be useful as biomarkers in patients with POAG.

Cited by 48 publications

References 23 publications

Discovery and Validation of Circulating Hsa-miR-210-3p as a Potential Biomarker for Primary Open-Angle Glaucoma

Discovery and Validation of Circulating Hsa-miR-210-3p as a Potential Biomarker for Primary Open-Angle Glaucoma

The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy

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