Diabetes affects corneal biomechanics and results in lower CH values than those in healthy control subjects, which may cause clinically relevant high IOP measurements independent of CCT.

Our study for the first time provides evidence that NLR and PLR may be useful as biomarkers in patients with POAG.

Subconjunctival injection of bevacizumab decreases the extent of chemically induced corneal neovascularization in guinea pigs. The antineovascular effect of bevacizumab is higher if the injection is performed simultaneously with the chemical cauterization.

Although frequency of ROP in Turkey is similar to that in the United States, the rate of severe ROP necessitating treatment seems to be higher in Turkey. Neonates with a gestational age of 32 weeks or less, a birth weight of less than 1,250 g, sepsis, and oxygen therapy may have a greater risk of developing ROP and screening should be intensified in the presence of these risk factors.

Our study for the first time provides evidence that PLR and NLR may be useful for predicting the prognosis of PEX patients and progression to PXG.

Objective: Previous studies have demonstrated that low plasma adiponectin concentrations are associated with essential hypertension. It has also recently been shown that adiponectin plays an essential role in the modulation of angiogenesis. These data led us to hypothesize that adiponectin might contribute to end-organ damage in hypertension. Methods: In the present study we have evaluated the relationship between plasma adiponectin concentrations and hypertensive retinopathy. One hundred and ten patients newly diagnosed with essential hypertension (EHT) (mean age, 46.79^5.0 years; body mass index (BMI), 26.47^2.23 kg/m 2 ; male/female ratio, 58/52) and 57 healthy normotensive control subjects (NT) (mean age, 46.84^5.4 years; BMI, 26.66^2.65 kg/m 2 ; male/female ratio, 33/24) were enrolled. Results: Plasma adiponectin levels were significantly lower in EHT than in NT (P , 0.001). In addition, adiponectin concentrations were strongly correlated with systolic and diastolic blood pressures in EHT (r ¼ 2 0.757, P , 0.001; r ¼ 20.761, P , 0.001) while there was no correlation in the NT group. Plasma adiponectin in patients with grade 0 hypertensive retinopathy (n ¼ 52) was significantly higher than that of the patients with grade 1 (n ¼ 30) and 2 (n ¼ 28) hypertensive retinopathy (P , 0.001 for each). Plasma adiponectin in patients with grade 0 hypertensive retinopathy was also significantly lower than that in the NT group (P , 0.001). The estimated threshold of plasma adiponectin concentration for hypertensive retinopathy was 17 mg/ml. This critical adiponectin level served largely to separate patients with retinopathy from those without. Conclusion: Our results have shown that plasma adiponectin concentrations decrease progressively with higher grades of hypertensive retinopathy even after correction for other atherogenic risk factors, suggesting that a critical adiponectin level is needed for the development of retinopathy. 152 233-240 European Journal of Endocrinology

No abstract

IH636 grape seed proanthocyanidin extract effectively suppressed cataract formation in rats. Routine consumption of grape seed proanthocyanidin extract in the form of food or dietary supplement may offer a prophylactic measure against onset and progression of cataract.