Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy

Abstract

PURPOSE: To evaluate the neutrophil-to-lymphocyte ratio (NLR) levels to predict the severity of infl ammation in thyroid ophthalmopathy (TO). METHODS: Fifty-six patients with TO and 40 healthy subjects were included in this study. TO patients were divided into two groups according to clinical activity score (CAS). Group 1 included 24 active TO patients and Group 2 included 32 inactive TO patients. The thyroid status, white blood cell (WBC), neutrophil, and lymphocyte counts were performed. NLR was calculated by dividing the neutrophil count by the lymphocyte count. RESULTS: The mean age was 53.6 ± 5.4 in active TO group, 54.2 ± 5.6 in inactive TO group, and 52.7 ± 5.2 in the control group. The WBC, neutrophil, lymphocyte and NLR levels were higher in patients with TO than in the control group (p < 0.05). A signifi cant difference in NLR was found between the inactive and active TO groups (p < 0.05). CONCLUSION: NLR values were found to be higher in patients with TO than in controls. NLRvalues were also found higher in active TO patients than in inactive TO patients (Tab. 3, Ref. 26). Text in PDF www.elis.sk.

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

“…MPV/PLT was surprisingly statistically lower in active than in inactive GO, thus further studies are needed to evaluate usefulness of this ratio. This partially stands in agreement with Celik et al who reported significantly higher WBC, neutrophil, lymphocyte counts, and NLR values in patients with active GO compared to inactive thyroid eye disease [ 28 ]. The similar profile of WBC system was described by Atilgan et al, although lymphocyte counts were statistically lower in patients with active GO [ 29 ].…”

“…Furthermore, there were statistical differences in WBC, lymphocyte counts and MLR between all groups. Similar results were obtained by Celik et al, who revealed that both WBC, neutrophil, lymphocyte counts and NLR values were significantly higher in the group of patients with GO compared with the controls [ 28 ]. Contrary to the above-mentioned results, there are reports showing no significant differences in NLR values between GD patients as compared with healthy subjects [ 44 ].…”

“…What is more, it was observed that activated T cells release cytokines, such as tumor necrosis factor α (TNF-α), interleukin 1 β (IL-1β), interleukin 6 (IL-6), and interleukin (IL-17), which results in the increased production and recruitment of neutrophils and macrophages. This hypothesis partially explains neutrophilia, increased monocyte counts, and MLR values in the course of GD which were observed in our research [ 5 , 12 , 28 , 29 , 44 , 46 ].…”

“…Literature data about the role of NLR, MLR and PLR in chronic autoimmune thyroid diseases are still lacking [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. There are only single studies evaluating the relationship between these direct and indirect blood-cell associated inflammatory markers and GO [ 28 , 29 ].…”

Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender

“…So NLR reflects both inflammation and stress response which are two important immune pathways. NLR has been investigated in several studies on cancer [22], cardiovascular disease [23], and thyroid disease [24,25]. But only one study so far had investigated the relationship between NLR and TN, which showed a negative association between high values of NLR and the presence or size of the nodules [26].…”