Effect of thyroid hormone status on complete blood cell count-derived inflammatory biomarkers in patients with moderate-to-severe Graves’ ophthalmopathy

Yuksel, Nilay; Saritas, Ozge; Yuksel, Erdem

doi:10.1007/s10792-023-02742-x

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…An earlier study reported higher NLR values in GO patients compared to the control group [6]. Yüksel et al reported higher NLR, MLR, mean platelet volume (MPV), and SII in both GO and Graves' patients compared to the control group [7]. In contrast with these results, Dağdeviren et al reported that NLR and lymphocyte levels were not significantly different in hyperthyroid patients compared to the control group [8].…”

Section: Introductionmentioning

confidence: 96%

Evaluation of hematologic inflammatory markers in Graves’ disease

ATLI,

DAYANAN

2023

Family Practice and Palliative Care

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Introduction: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) have been used as new inflammatory markers in certain autoimmune diseases to assess the severity of inflammation. The current study aimed to evaluate the changes in neutrophil and lymphocyte series in hyperthyroid patients and to investigate whether NLR, PLR, and SII may be markers of inflammation. Methods: This cross-sectional study was conducted with 207 Graves’ patients and 120 healthy controls between 2018-2022 years. Hematologic parameters, thyroid function tests, age and gender were recorded. The NLR, PLR and SII values of all subjects were calculated. Firstly, groups were composed as Graves' group and participants without thyroid disorder as control group. Secondly, Graves' patients composed as two groups before treatment and after antithyroid treatment. These groups were compared with each other in terms of descriptive data and hematological parameters. Results: The patient and control groups were similar in terms of gender (p=0.522) and age (p=0.051). Graves’ patients had a significantly lower NLR than the control group (p=0.004). There was no significant difference between the groups in terms of PLR (p=0.120) and SII (p=0.577). Patients’ baseline TSH-receptor antibodies (TRAb) levels had a significant positive correlation with fT3 (r:0.283, p<0.001), fT4 (r:0.252, p<0.001) and Thyroid stimulating immunoglobulin (TSI) (r:0.673, p<0.001). There was no significant correlation between TRAb and TSI levels, inflammatory markers, and hematological parameters. Conclusions: Graves’ patients had lower NLR compared to the control group. The patient and control groups did not have a significant difference with regard to PLR and SII. Thyroid autoantibody levels and inflammatory markers did not have a significant correlation. Keywords: Hyperthyroidism, inflammation, neutrophils, lymphocytes

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Section: Introductionmentioning

confidence: 96%