Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms

Borges, Márcia Helena; Alves, Dalton Luiz Ferreira; Raslan, D. S.; Piló‐Veloso, Dorila; Rodrigues, Veridiana M.; Homsi-Brandeburgo, Maria Inês; Lima, Maria Elena de

doi:10.1016/j.jep.2004.12.014

Cited by 81 publications

(57 citation statements)

References 30 publications

(33 reference statements)

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“…This finding does not agree with several studies that found positive results by using in vitro neutralization methods of plant extracts for anti-snake venom assays. However, one work showed similar results regarding tannins of Musa paradisiaca extract that presented in vitro neutralization activities, but not in vivo (13). This can be attributed to the fact that tannins are able to non-specifically bind to N. kaouthia venom proteins and precipitate them, thus provoking the anti-lethal effects.…”

Section: Discussionmentioning

confidence: 94%

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Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom

Sia¹,

Vejayan²,

Jamuna³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:In the present study, the effectiveness of Mimosa pudica tannins (MPT) in neutralizing the lethality of Naja kaouthia venom was compared with commercially derived tannins. Preincubation of MPT with N. kaouthia venom maintained 100% survival of mice after 24 hours. The mouse group in which there was no preincubation, no protection against the effects of the venom was observed. M. pudica tannin was found to be more effective in neutralizing the lethality of N. kaouthia venom when compared to commercial tannic acid. Two protein spots were missing in the two-dimensional gel electrophoresis (2-DE) of the MPT treated mouse indicating the down-regulation of venom proteins. The results from this study indicated that tannins obtained from M. pudica are better than tannic acid in neutralizing the lethality of N. kaouthia venom in vitro. However, further investigations are required to establish that M. pudica has potential for treating N. kaouthia snakebites.

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Section: Discussionmentioning

confidence: 94%

“…The International Medical University Research Fund BMS 102_2007 (13) and the Malaysian Ministry of Science and Technology (project number 02-02-10-SF0033) provided the financial grants. …”

Section: Financial Sourcementioning

confidence: 99%

Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom

Sia¹,

Vejayan²,

Jamuna³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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“…[25][26][27] Porém, os efeitos locais, particularmente o edema, não são neutralizados, dificultando o tratamento dos acidentados. [28][29][30][31] Alguns estudos mostram o uso popular de espécies vegetais [32][33][34][35][36][37] e a eficácia da heparina no tratamento das reações locais por envenenamentos ofídicos. [38][39][40] A espécie Peltodon radicans é conhecida popularmente por paracari, [41][42][43] sendo encontrada na região Amazônica principalmente em terrenos arenosos e matas de terra firme.…”

Section: Introductionunclassified

Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae)

Costa¹,

Dos-Santos²,

Alcântara³

et al. 2008

Quím. Nova

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ArtigoDedicamos este trabalho à Helena Ferraz, que nasceu e cresceu, e que me viu também nascer e crescer, em um daqueles muitos rincões mineiros encostados na Serra da Mantiqueira. Mantiqueira -do tupi "Amantikir" -a montanha que chora, agora chora e choramos ainda mais, por você, Helena. *e-mail: aalcantara@zeus.qui.ufmg.br Recebido em 4/6/07; aceito em 11/10/07; publicado na web em 10/3/08 CHEMICAL CONSTITUENTS AND ANTIEDEMATOGENIC ACTIVITY OF Peltodon radicans (Lamiaceae). Most of the snakebite incidents in the Amazon region involve Bothrops atrox, whose venom presents the most potent edematogenic and necrotic activities in the genus. This work describes the studies of isolation of the chemical constituents and antiedematogenic activity of the species Peltodon radicans (Lamiaceae), which is used in the treatment of snakebites and scorpion stings in the region. The extracts presented aliphatic hydrocarbons, 3β-OH,β-amirin (1), 3β-OH,α-amirin (2), β-sitosterol (3), stigmasterol (4), ursolic acid (5), 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid (tormentic acid, 6), methyl 3β-hydroxy,28-methyl-ursolate (7), sitosterol-3-O-β-D-glucopyranoside (8), and stigmasterol-3-O-β-D-glucopyranoside (9). The flower extracts presented the higher antiedematogenic activity. This is the first report on the study of the flowers, stem, and roots of this plant. CONSTITUINTES QUÍMICOS E ATIVIDADE ANTIEDEMATOGÊNICA DE Peltodon radicans (LAMIACEAE)HabdelKeywords: Peltodon radicans; antiedematogenic activity; triterpenes. INTRODUÇÃOSegundo a Organização Mundial da Saúde, anualmente cerca de 2,5 milhões de pessoas sofrem acidentes ofídicos no mundo, com 125 mil mortes.1 Esses acidentes representam um enorme problema de saúde pública, especialmente em países tropicais.2-4 Na África, são registrados cerca de 500 mil acidentados por ano, com 40% dos casos hospitalizados e 20.000 óbitos.5 Na Ásia há entre 25 e 35 mil óbitos por ano.6 O Ministério da Saúde do Brasil registra entre 19 e 22 mil acidentes ofídicos por ano, com aproximadamente 0,45% de letalidade.7 Quando informado o gênero da serpente, Bothrops foi responsável por 90,5% dos acidentes ofídicos, envolvendo 0,31% de óbito.Bothrops atrox (jararaca) é encontrada vastamente na região Norte do Brasil, 8,9 habitando ambientes úmidos de zonas rurais ou periféricas das grandes cidades, onde haja facilidade para proliferação de roedores.10-13 Na Amazônia essa espécie ocorre em altas densidades, principalmente em florestas, apresentando hábitos noturnos. Os jovens ingerem presas exotérmicas e os adultos, presas endotérmicas, ocorrendo portanto variação ontogenética para a peçonha dessa espécie.14-16 Os venenos de B. atrox são constituídos principalmente por proteínas com atividade enzimática, apresentando variações tanto inter quanto intraespecíficas. [17][18][19] Esses venenos induzem reações locais imediatas como dor, edema, hemorragia e mionecrose, 20 podendo levar à perda tecidual abundante, assim como de parte ou de todo o membro atingido. Dentre as atividades biológicas sistêmicas des...

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“…In addition, banana peel extracts show anti-microbial activities against P. gingivalis and A. actinomycetemcomitans [31]. Interestingly, Musa paradisiaca may also offer some protection against snake venom toxicity [32]. Green bananas made into flour have been observed to provide beneficial effects in enhancing male semen counts at a low consumption dose (500 mg/kg/day), although at high doses (1000 mg/kg/day) significant lower sperm cell figure 1.…”

Section: Green Bananas and Health Benefitsmentioning

confidence: 99%

Let’s Go Bananas! Green Bananas and their Health Benefits

Apostolopoulos

Antonipillai

Tangalakis

et al. 2017

Prilozi

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Bananas have enormous health benefits as a food for both animals and humans. They have been used as a complimentary medicine to treat pathological conditions since ancient times. Recently, there has been increased interest in the scientific validity of the beneficial effects of bananas in alleviating and treating disease conditions including, ulcers, infections, diabetes, diarrhea, colitis and blood pressure. Herein, we write on the potential therapeutic and functional benefits of certain species of bananas when consumed green as well as considering the properties of extracts from the non-fruit parts of the plant. We conclude that green bananas appear to deliver an array of health and therapeutic benefits

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Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms

Cited by 81 publications

References 30 publications

Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom

Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom

Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae)

Let’s Go Bananas! Green Bananas and their Health Benefits

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