Neurofibroma of kidney: An uncommon neoplasm and diagnostic dilemma with solitary fibrous tumor

Mondal, Santosh Kumar; Mallick, Mamata Guha; Bandyopadhyay, Ranjana; Mondal, Palash

doi:10.4103/0973-1482.73347

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…The presence of the above immunohistochemical properties can differentiate SFTs from other malignancies, such as neurofibroma [19]. In addition, the presence of certain cytogenetic abnormalities, such as translocation t(X;18), can help rule out synovial sarcoma [17].…”

Section: Resultsmentioning

confidence: 99%

Solitary Fibrous Tumors of the Kidneys: Presentation, Evaluation, and Treatment

et al. 2013

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Introduction: Renal solitary fibrous tumors (SFTs) are spindle cell neoplasms of mesenchymal origin, and very rare with only 46 cases reported worldwide to date. It is crucial to differentiate this tumor from other tumors of the kidney, so as to avoid unnecessary treatment. Therefore, our objective was to review reports of renal SFTs, their clinical presentations, imaging methods, and surgical management, updated to 2013. Material and Methods: We retrospectively reviewed articles published in the USA, Europe, and Asia from 1996 to date using PubMed, Medscape, Medline, and several major journals. We report on areas of controversy and well-established guidelines. Results: We reviewed 58 articles which confirmed, with a high level of evidence-based medicine, that the male-to-female ratio is equal and their most common presentation is an incidental finding on a radiological study, in which it is difficult to differentiate them from renal cell carcinoma. Nephrectomy is the gold standard treatment, with almost no recurrence. Conclusions: In symptomatic patients, complete surgical resection of renal SFTs may provide a very good outcome, with almost no recurrence.

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Section: Resultsmentioning

confidence: 99%

Solitary Fibrous Tumors of the Kidneys: Presentation, Evaluation, and Treatment

et al. 2013

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“…The differential diagnosis of SFT via imaging is difficult due to its variable signal intensity on MRI scans (29). Differentiation from meningioma, schwannoma, neurofibroma, metastases and lymphoma was required (30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report

2023

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Solitary fibrous tumor (SFT) of the central nervous system is a rare spindle cell tumor of mesenchymal origin. The present study reports the case of a 44-year-old male patient with SFT. Magnetic resonance imaging demonstrated that the majority of the intracranial tumors exhibited uneven low signals on T1-weighted imaging (T1WI) and low mixed signals on T2WI, and there was an enhancement on enhanced scanning. Furthermore, the distal part of the left occipital lobe exhibited hypersignals on T1WI and T2WI, and this was significantly enhanced following enhanced scanning. The lower part of the scalp exhibited low signals on T1WI and high signals on T2WI, and there was no notable enhancement following enhanced scanning. Magnetic resonance spectroscopy demonstrated an elevated choline/creatine peak in the solid part of the tumor. Under the microscope, the tumor exhibited characteristic 'staghorn-shaped' blood vessels. As SFT is difficult to differentially diagnose via imaging, immunohistochemical analysis of CD34, vimentin and signal transducer and activator of transcription 6 was performed for the definitive diagnosis of SFT. Of note, surgical resection was the preferred treatment for SFT; however, due to the rarity of the tumor, subsequent adjuvant therapy and prognosis require further investigation.

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