Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report

Abstract

Solitary fibrous tumor (SFT) of the central nervous system is a rare spindle cell tumor of mesenchymal origin. The present study reports the case of a 44-year-old male patient with SFT. Magnetic resonance imaging demonstrated that the majority of the intracranial tumors exhibited uneven low signals on T1-weighted imaging (T1WI) and low mixed signals on T2WI, and there was an enhancement on enhanced scanning. Furthermore, the distal part of the left occipital lobe exhibited hypersignals on T1WI and T2WI, and this was significantly enhanced following enhanced scanning. The lower part of the scalp exhibited low signals on T1WI and high signals on T2WI, and there was no notable enhancement following enhanced scanning. Magnetic resonance spectroscopy demonstrated an elevated choline/creatine peak in the solid part of the tumor. Under the microscope, the tumor exhibited characteristic 'staghorn-shaped' blood vessels. As SFT is difficult to differentially diagnose via imaging, immunohistochemical analysis of CD34, vimentin and signal transducer and activator of transcription 6 was performed for the definitive diagnosis of SFT. Of note, surgical resection was the preferred treatment for SFT; however, due to the rarity of the tumor, subsequent adjuvant therapy and prognosis require further investigation.

a case report on an intracranial solitary fibrous tumor

“…In another study, a 30-year-old man was diagnosed with SFT that was close to the temporal lobe of the right side and thickened the temporal bone next to it. The patient also exhibited dysarthria and left facial nerve palsy, as well as lessened muscle power in his left upper and lower limbs [1,3]. This patient experienced hemiparesis of the left arm and left foot in addition to a significant headache, and the SFT was found to be in the right frontal region.…”

“…One percent of all primary CNS tumors are this kind. [3] Cerebellopontine angle, spinal dura mater, parasagittal region, meninges, and ventral tegmental area SFTs have all been documented. [1] The disease often affects individuals between the ages of 20 and 70, and both men and women have equal chances of contracting it.…”

Solitary fibrous tumor in the saddle area treated with neuroendoscopic surgery and proton therapy: A case report and literature review

“…Due to similar histological features, immunophenotype, and the common chromosome 12q13 inversion, nerve growth factor-induced gene A binding protein 2 (NAB2) and STAT6 gene fusion ( 3 ), the World Health Organization (WHO) central nervous system (CNS) classification from 2016 used the joint diagnostic terminology ‘Solitary fibrous tumor/hemangiopericytoma’ to describe these disorders and classified them into grades I, II and III ( 4 ). However, the distinction between the two types was no longer clinically significant due to the pronounced clinical and histopathological overlap ( 5 ). The 2021 WHO classification of CNS tumors changed the previously used term ‘hemangiopericytoma’ to the term SFT ( 6 ).…”