Neovascularisation associated with posterior uveitis.

Aqueous flare in patients with monocular iris atrophy and uveitis. A laser flare and iris angiography study

“…2. By reducing inflammation, thereby diminishing the stimulus to neovascularization (Graham et al 1987). The inflammatory theory is to some degree supported by the findings of Murray et al (1990b).…”

“…However, it has been suggested that inflammation per se might act as a stimulus for neovascularization. Retinal neovascularization has been found in cases of uveitis without evidence for capillary closure (Graham et al 1987). Kalina et al (1990) have reported 9 patients with pars planitis and neovascularization of the optic disc.…”

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

“…The finding of 26 patients with retinal neo vascularisation following posterior uveitis (8 with sarcoidosis, 7 with Behcet's disease and 11 with retinal vasculitis) has been communi cated [70], A proliferative retinitis was de scribed in 7 patients (11 eyes) including neo vascularisation of the optic disc in 2 eyes [71]. In all cases, the neovascularisation was ac companied by impaired peripheral capillary circulation.…”

Angiogenic Activity of Vitreous Extract Obtained from Rabbit Eyes with Endotoxin-lnduced Uveitis

“…Angiogenesis is observed in various eye disorders, such as proliferative diabetic reti nopathy, retinopathy of prematurity, age-re lated macular degeneration, central and branch retinal vein occlusions, as well as in uveitis [1][2][3][4][5]. The various factors participat ing in angiogenesis had previously been re viewed by Folkman and Klagsbrun [6] and involve growth factors, and tumor-necrotiz ing factor as well as the cyclooxygenase prod ucts of arachidonic acid; prostaglandins and prostacyclin [7][8][9][10].…”

“…The various factors participat ing in angiogenesis had previously been re viewed by Folkman and Klagsbrun [6] and involve growth factors, and tumor-necrotiz ing factor as well as the cyclooxygenase prod ucts of arachidonic acid; prostaglandins and prostacyclin [7][8][9][10]. Leukotrienes, the lipoxy neovascularization of the retina [1] and optic disc [3,5], In the intact eye the cornea is avascular and its invasion by newly formed blood ves sels (angiogenesis or neovascularization) oc curs only in the presence of angiogenic factor/s. Therefore, induction of corneal neovas cularization in rabbits [20], mice [21 ] and rats [22] has been widely used as an assay to assess the angiogenic activity of various substances following their intracorneal implantation.…”