Angiogenic Activity of Vitreous Extract Obtained from Rabbit Eyes with Endotoxin-lnduced Uveitis

Abstract

The effect of rabbit vitreous with endotoxin-induced uveitis was investigated for its role in the modulation of rat corneal neovascularization (NV). Elvax pellets implanted into at cornea contained either uveitic vitreous, intact vitreous or Elvax alone. The latter two kinds of pellets did not elicit NV. Uveitic vitreous pellets caused, in 100% of eyes, a persistent NV with maximal growth on the 10th day post implantation. Prostaglandin E₂ and leukotriene B₄ levels in the uveitic rabbit vitreous at 36 h postendotoxin injection were 7- and 5-fold higher than baseline, respectively. Histopathologically, the neovascularized cornea showed a significant inflammatory reaction attributable to the uveitic vitreous extract.