Aqueous flare in patients with monocular iris atrophy and uveitis. A laser flare and iris angiography study

Norrsell, Kerstin; Holmér, Anna-Karin; Jacobson, Helena

doi:10.1034/j.1600-0420.1998.760404.x

Cited by 22 publications

(19 citation statements)

References 14 publications

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“…It is noteworthy that flare levels do not change with anti-inflammatory Review CME treatment and remain stable over months or years in this entity [7,37,38]. A relatively mild and stable breakdown of the blood-aqueous barrier has been reported in FU even after cataract surgery [33,36,39,40]. LFP studies have confirmed the clinical observations on the disease course and helped in explaining the benign nature of FU [41].…”

Section: Fuchs' Uveitissupporting

confidence: 60%

Laser flare photometry and its use in uveitis

Tuğal-Tutkun

Yalçındağ

Herbort

2012

Expert Review of Ophthalmology

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Section: Fuchs' Uveitissupporting

confidence: 60%

Laser flare photometry and its use in uveitis

Tuğal-Tutkun

Yalçındağ

Herbort

2012

Expert Review of Ophthalmology

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“…Furthermore, after 1 week, aqueous flare was only slightly increased, and 6 weeks following surgery, eyes with FHU had reestablished their BAB to preoperative levels. This corresponds to findings published by Norsell et al [6], who observed that cataract surgery did not permanently change aqueous flare values in selected cases with FHU.…”

Section: Discussionsupporting

confidence: 59%

“…Anterior chamber inflammation in this condition is mild with trace aqueous flare and few aqueous and vitreous inflammatory cells [6, 7]. As cataract formation is a common complication of FHU, cataract surgery is frequently performed in these eyes.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Blood-Aqueous Barrier Breakdown after Phacoemulsification in Fuchs’ Heterochromic Uveitis

Nguyen¹,

Küchle²,

Naumann³

2005

Ophthalmologica

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Purpose: To quantify the breakdown of the blood-aqueous barrier (BAB) following phacoemulsification with posterior chamber lens implantation in eyes with Fuchs’ heterochromic uveitis (FHU). Patients and Methods: In this retrospective study, 19 eyes of 19 patients with FHU (mean age 38 ± 14 years) and 35 eyes of 35 patients with senile cataracts (mean age 63 ± 9 years) underwent phacoemulsification with one-piece PMMA posterior chamber lens implantation. Aqueous flare was quantified using the laser flare-cell meter (LFCM, Kowa FC-1000) following medical pupillary dilation preoperatively and 1, 3, and 5 days, then 1 and 6 weeks and 6 months postoperatively. Results: Mean preoperative aqueous flare (in photon counts per millisecond) in FHU vs. controls was 11.7 ± 3.5 vs. 5.8 ± 1.7. Following cataract surgery, mean aqueous flare increased to 27.8 ± 4.4 vs. 16.0 ± 4.5 on day 1, decreased to 23.6 ± 4.0 vs. 11.8 ± 3.5 on day 3, and to 18.0 ± 3.0 vs. 9.5 ± 1.7 on day 5. In FHU eyes, it was 13.9 ± 2.7 after 1 week, and had returned to preoperative levels after 6 weeks (10.9 ± 2.5) and remained stable for up to 6 months (mean 10.3 ± 2.2). Pre- and postoperatively, aqueous flare values were 2–3 times higher in FHU eyes than in control eyes with senile cataract (p = 0.01). No postoperative complications such as fibrin formation, synechiae, macrophages on the intraocular lens optic or endophthalmitis were observed in any of the patients. Conclusions: BAB breakdown following phacoemulsification with posterior chamber lens implantation is relatively mild in eyes with FHU and the BAB appears to be fully reestablished to preoperative levels 6 weeks postoperatively, explaining the usually good outcome of cataract surgery in this condition.

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“…Alteration of the bloodaqueous barrier (BAB) in patients with Fuchs syndrome has been demonstrated by iris fluorescein angiography. 6 Our recent study using laser flare-cell meter (LFCM) analysis has confirmed that aqueous flare values and cell counts are increased in the affected eyes with Fuchs syndrome. 7 However, it is not yet known which clinical parameters, such as patients' age, sex, laterality, best-corrected visual acuity (BCVA), duration of disease, KP, iris depigmentation, intraocular pressure, and posterior subcapsular lens opacities are associated with these changes.…”

Section: Introductionmentioning

confidence: 94%

Aqueous flare and cells in Fuchs syndrome

Wang

Zhou

Yang

et al. 2007

Eye

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) were also significantly higher in Fuchs syndrome (5.09 ± 4.84) than in normal controls (1.14 ± 1.03, P ¼ 0.000). The flare values were positively correlated with the cell counts (r ¼ 0.331, P ¼ 0.001). Both flare values and cell counts were higher in eyes with keratic precipitates scored 2 þ or 3 þ as compared to those with a 1 þ score. Higher flare values and cell counts were also observed in eyes with a 2 þ or 3 þ iris depigmentation score as compared to those with a 1 þ score. No difference was found between flare values and cell counts and other parameters. Conclusion Breakdown of blood-aqueous barriers and increased cell counts are present in the affected eyes in patients with Fuchs syndrome. These changes are positively associated with the degree of keratic precipitates and iris depigmentation.

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Aqueous flare in patients with monocular iris atrophy and uveitis. A laser flare and iris angiography study

Cited by 22 publications

References 14 publications

Laser flare photometry and its use in uveitis

Laser flare photometry and its use in uveitis

Quantification of Blood-Aqueous Barrier Breakdown after Phacoemulsification in Fuchs’ Heterochromic Uveitis

Aqueous flare and cells in Fuchs syndrome

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