Laser flare photometry and its use in uveitis

Tuğal-Tutkun, İlknur; Yalçındağ, F Nilüfer; Herbort, Carl P.

doi:10.1586/eop.12.47

Cited by 14 publications

(13 citation statements)

References 58 publications

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“…The intensity of flare and peaks of light scattered from the particles in the aqueous reflect the inflammation and cells in the anterior chamber, respectively. It is important to note that any large particles in the aqueous that can produce peaks, such as blood cells, pigment, debris, or other cells, cannot be differentiated from inflammatory cells [ 15 , 16 ]. In the present study, the number of cells in the anterior chamber increased and peaked immediately in the study eye after the injection in groups 1 and 2 (Fig.…”

Section: Resultsmentioning

confidence: 99%

Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa

et al. 2021

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Background Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to investigate the safety, feasibility, and short-term efficacy of intravitreal injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) in participants with advanced stage RP. Methods This non-randomized phase I clinical trial enrolled 14 participants, categorized into three groups based on a single dose intravitreal BM-MSC injection of 1 × 106, 5 × 106, or 1 × 107 cells. We evaluated signs of inflammation and other adverse events (AEs). We also assessed the best corrected visual acuity (BCVA), visual field (VF), central subfield thickness (CST), and subjective experiences. Results During the 12-month period, we noticed several mild and transient AEs. Interestingly, we found statistically significant improvements in the BCVA compared to baseline, although they returned to the baseline at 12 months. The VF and CST were stable, indicating no remarkable disease progression. We followed 12 participants beyond the study period, ranging from 1.5 to 7 years, and observed one severe but manageable AE at year 3. Conclusion Intravitreal injection of BM-MSCs appears to be safe and potentially effective. All adverse events during the 12-month period required observation without any intervention. For the long-term follow-up, only one participant needed surgical treatment for a serious adverse event and the vision was restored. An enrollment of larger number of participants with less advanced RP and long-term follow-up is required to evaluate the safety and efficacy of this intervention. Trial registration ClinicalTrials.gov, NCT01531348. Registered on February 10, 2012

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Section: Resultsmentioning

confidence: 99%

Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa

et al. 2021

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“…С целью дифференциальной диагностики целесообразно выполнение лазерной фотометрии, позволяющей количественно и объективно оценить клеточную инфильтрацию и опалесценцию влаги передней камеры и стекловидного тела [81]. В немногочисленных работах, использующих лазерную фотометрию для оценки степени повреждения гематоретинального барьера при ОВС, было отмечено незначительное повышение показате-лей, максимальные значения которых составили 9,9 ± 2,4 фт/мс [64].…”

Section: этиология и патогенез нейроретиноваскулита с вторичной окклюunclassified

The main aspects of retinal vein occlusion etiopathogenisis in young adults. Part I. Neuroretinovasculitis (prothrombotic potential, clinical manifestations)

Тульцева

Николаевна²,

Lisochkina

et al. 2018

Ophthalmology Reports

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This review is dedicated to the neuroretinovasculitis, which is the leading cause of retinal vein occlusion in young adults. Presumed etiological factors, possible pathogenic mechanisms, and clinical manifestation are analyzed. Advisability of multidisciplinary approach in management and individual approach in treatment of patients with neuroretinovasculitis with secondary retinal vein occlusion are justified.

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Section: Introductionmentioning

confidence: 99%

“…It has been shown that, flare measurements are considered to be a predominant sign for predicting inflammatory recurrences in pediatric chronic anterior uveitis. 15 Additionally, previous studies have demonstrated the correlation of high laser flare values with the severity of ocular complications in pediatric uveitis. 16,17 In this study, our purpose was to compare the LFP measurements, with AC cell grading by slit-lamp examination according to the SUN classification, to monitor the intraocular inflammation in children with chronic anterior uveitis.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of laser flare photometry versus slit-lamp cell measurement in pediatric chronic non-infectious anterior uveitis

Yalçındağ

Köse

Temel

2022

European Journal of Ophthalmology

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Purpose To evaluate the role of laser flare photometry (LFP) for monitoring the course of intraocular inflammation in children with chronic anterior uveitis. Methods Seventy-six eyes of 43 children with non-infectious chronic anterior uveitis were reviewed retrospectively. Results The median follow-up was 48.6 ± 23.1 months. Patients on immunosuppressive treatment at last follow-up, showed significantly higher flare values than patients who discontinued treatment (20.47 ± 15.49 vs. 6.33 ± 4.87 p < 0.001). The higher LFP values were correlated with the duration of immunosuppressive treatment, total duration of topical corticosteroid use and the risk for development of ocular complications at all follow-ups (all p < 0.001). No significant correlation was found between the AC cell grades and the duration of immunosuppressive treatment, topical corticosteroid use and the prevalence of complications. Conclusion LFP measurements have a predictive value of monitoring the course of uveitis and the occurrence of ocular complications, and it should be considered as a primary modality to monitor intraocular inflammation in children with chronic anterior uveitis.

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Laser flare photometry and its use in uveitis

Cited by 14 publications

References 58 publications

Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa

Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa

The main aspects of retinal vein occlusion etiopathogenisis in young adults. Part I. Neuroretinovasculitis (prothrombotic potential, clinical manifestations)

Comparative study of laser flare photometry versus slit-lamp cell measurement in pediatric chronic non-infectious anterior uveitis

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