Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [
            <i>Morus Alba</i>
            L. (Moraceae)]

Li, Jing; Dou, Lu; Chen, Shuangfeng; Zhou, Hong-Hao; Mou, Fangzheng

doi:10.1080/13880209.2021.1995005

Cited by 5 publications

(3 citation statements)

References 38 publications

(35 reference statements)

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“…However, it is expected that the reason why Pectinex only increased the content of 5-CQA and 4-CQA like this can be elucidated through future research. Several studies reported that 5-CQA had an anti-inflammatory effect in brain disease by inhibiting proinflammatory cytokines 56 , high potential for the development of human immunodeficiency virus-1 drug by inhibiting its reverse transcriptase activity 57 , and improved hepatic lipid accumulation and inflammation by regulating miR-34a 58 . In addition, 4-CQA was reported to have antioxidant activity 59 .…”

Section: Discussionmentioning

confidence: 99%

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

Han

Lee

Jung

et al. 2022

Sci Rep

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Mulberry leaf (Mori Folium) extract (MLE) is known to have anti-obesity effects. In this study, the enhanced effects of MLE after bioconversion treatment using Pectinex (BMLE) on obesity were explored, and the underlying mechanisms were investigated using the active components, neochlorogenic acid (5-CQA) and cryptochlorogenic acid (4-CQA), whose amounts were increased by bioconversion of MLE. Both MLE and BMLE inhibited lipid accumulation in 3T3-L1 adipocytes without cytotoxicity and suppressed the expression of CCAAT/enhancer-binding protein alpha (C/EBPα). In addition, MLE and BMLE decreased high-fat diet-induced adipose tissue mass expansion. Notably, BMLE significantly increased antiadipogenic and anti-obesity effects compared to MLE in vitro and in vivo. The active ingredients increased by bioconversion, 5-CQA and 4-CQA, inhibited the protein levels of C/EBPα and the mRNA levels of stearoyl-CoA desaturase 1 (Scd1). These findings provide new insights into the therapeutic possibility of using bioconversion of MLE, by which upregulation of 5-CQA and 4-CQA potently inhibits adipogenesis.

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Section: Discussionmentioning

confidence: 99%

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

Han

Lee

Jung

et al. 2022

Sci Rep

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“…Neochlorogenic acid significantly reduced the total reverse transcriptase gene expression identified by PCR compared to the control (6.01 versus 35.42, p 0.0001). Neochlorogenic acid may have an effect on sarcoma, the epidermal growth factor receptor, and hemopoietic cell kinase, thus suppressing HIV-1 infection, according to an enrichment study [62].…”

Section: Antiviral Effect Of Ca Against Human Immunodeficiency Virus ...mentioning

confidence: 99%

Antiviral and Anti-SARS-CoV-2 Activity of Natural Chlorogenic Acid and Its Synthetic Derivatives

Aljehany¹

2022

Arch Pharm Pract

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Since the dawn of time, several viral epidemics have swept the globe, among them the current COVID-19 outbreak. The ongoing emergence and propagation of novel viral illnesses have compelled researchers to seek new therapeutic approaches that can get beyond the drawbacks of antivirals that are available right now. Medicinal plants have historically offered treatments for a range of illnesses. These bioactive compounds serve as the foundation for many "modern" pharmaceuticals. One of the essential polyphenols in various medicinal plants is Chlorogenic acid (CA), an ester of caffeic and quinic acid. Extensive research has revealed that CA possesses anti-inflammatory, anticarcinogenic, and antioxidant properties. This review aims to briefly summarise CA and its derivative's antiviral properties on various human viral diseases and their ability to fight the current COVID-19 disease. This review summarises CA antiviral action on the following viruses: influenza A virus (H1N1/H3N2/H7N9), hepatitis C virus (HCV) and hepatitis B virus (HBV), human immunodeficiency virus (HIV), infectious bronchitis virus (IBV), porcine reproductive and respiratory syndrome virus (PRRSV), herpes simplex virus (HSV)-1, enterovirus 71 (Ent 71), adenoviruses (AdenV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review will open the way for developing and designing potentially effective and broad-spectrum CA-based antiviral medicines.

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“…Neochlorogenic acid (5-caffeoylquinic acid) is also a natural polyphenolic compound found in different plant sources and previous studies have shown that this compound has outstanding antiviral activities [37]. A previous study indicated that the performed cell experiments showed that neochlorogenic acid has a good inhibitory effect on the HIV-1 RT enzyme and may also inhibit HIV through four targets: haemopoietic cell kinase (HCK), epidermal growth factor receptor (EGFR), sarcoma (SRC), and 3-phosphoinositide dependent protein kinase 1 (PDPK1) [38]. Moreover, neochlorogenic acid may bind HIV-2 RT.…”

mentioning

confidence: 99%

Interactions and mechanisms of phenolic compounds with human immunodeficiency virus-1 Tat protein

S. Delos Santos,

A. Santos,

M. Mendoza

2024

IJPHS

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Human immunodeficiency virus remains a serious health threat, with an increase of 24% newly cases globally. Targeting Tat protein is an emerging therapeutic strategy for inhibiting the feedback loop that drives the exponential increase in viral transcription and particle production of the virus. The study aimed to determine the inhibitory potential of phenolic compounds from Ricinus communis L. and Jatropha curcas L., against the Tat C protein using in silico techniques. Phenolic compounds identified from both plants were screened by absorption-distribution-metabolism-excretion (ADME) analysis using drug-likeness prediction. Molecular docking analysis of the compounds with drug-like properties against the receptor and ligand-protein complexes’ analysis and visualization were performed. The results revealed three phenolic compounds with the highest negative binding affinity to the receptor’s active site: ellagic and neochlorogenic acids with - 7.2 kcal/mol and isohemiphloin with -7.3 kcal/mol. The interacting amino acids of the complexes were majorly His13, Lys19, Lys28, Thr64, His65, Gln66, Pro70, Gln72, and Pro73 via non-covalent interactions: hydrogen bonds, hydrophobic, and electrostatic interactions. The identified phenolic compounds provide a core structure that can be candidate for plant-based antiviral drugs development to potentially aiding in the virus’s therapeutic challenge.

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Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [ Morus Alba L. (Moraceae)]

Cited by 5 publications

References 38 publications

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

Antiviral and Anti-SARS-CoV-2 Activity of Natural Chlorogenic Acid and Its Synthetic Derivatives

Interactions and mechanisms of phenolic compounds with human immunodeficiency virus-1 Tat protein

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