The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

Han, Joo‐Hui; Lee, Hyung-Won; Jung, Sungyup; Cho, Chong Woon; Kim, Tae Jeong; Kang, Jong Seong; Myung, Chang‐Seon

doi:10.1038/s41598-022-23856-9

Cited by 3 publications

(3 citation statements)

References 68 publications

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“…Additionally, some of these compounds may directly interfere with the processes involved in fat cell differentiation and lipid storage, further contributing to their antifat accumulation effects. In previous examined MLE have been studied for their potential in reducing fat accumulation, especially in the context of obesity . The active compounds in mulberry leaves may inhibit the differentiation of fat cells (adipocytes) and reduce the level of accumulation of fat within these cells.…”

Section: Discussionmentioning

confidence: 99%

“…In previous examined MLE have been studied for their potential in reducing fat accumulation, especially in the context of obesity. 53 The active compounds in mulberry leaves may inhibit the differentiation of fat cells (adipocytes) and reduce the level of accumulation of fat within these cells. This effect can be enhanced through certain processes like bioconversion, which may increase the bioavailability and efficacy of the active compounds; thus, both MLE and nCGA possess the ability to alleviate the severity of steatohepatitis and diabetic fatty liver.…”

Section: Journal Of Agricultural Andmentioning

confidence: 99%

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Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice

Tsai,

Wang,

Tsai

et al. 2024

J. Agric. Food Chem.

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There are many complications of type 2 diabetes mellitus. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two complications related to the increased lipid accumulation in the liver. Previous studies have shown that mulberry leaf water extract (MLE) has the effect of lowering lipid levels in peripheral blood, inhibiting the expression of fatty acid synthase (FASN) and increasing the activity of liver antioxidant enzymes superoxide dismutase (SOD) and catalase. Our study aimed to investigate the role of MLE and its main component, neochlorogenic acid (nCGA), in reducing serum lipid profiles, decreasing lipid deposition in the liver, and improving steatohepatitis levels. We evaluated the antioxidant activity including glutathione (GSH), glutathione reductase (GRd), glutathione peroxidase (GPx), glutathione S-transferase (GST), and superoxide dismutase (SOD), and catalase was tested in mice fed with MLE and nCGA. The results showed a serum lipid profile, and fatty liver scores were significantly increased in the HFD group compared to the db/m and db mice groups, while liver antioxidant activity significantly decreased in the HFD group. When fed with HFD + MLE or nCGA, there was a significant improvement in serum lipid profiles, liver fatty deposition conditions, steatohepatitis levels, and liver antioxidant activity compared to the HFD group. Although MLE and nCGA do not directly affect the blood sugar level of db/db mice, they do regulate abnormalities in lipid metabolism. These results demonstrate the potential of MLE/nCGA as a treatment against glucotoxicityinduced diabetic fatty liver disease in animal models.

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Section: Discussionmentioning

confidence: 99%

Section: Journal Of Agricultural Andmentioning

confidence: 99%

Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice

Tsai,

Wang,

Tsai

et al. 2024

J. Agric. Food Chem.

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“…M. alba is an Asian medicinal plant with roots, fruits, and seeds used to lower glucose levels, reduce liver damage, and improve oxidative stress[ 113 , 114 ]. Flavonoids, polysaccharides, and alkaloids are key active components in M. alba leaves that alleviate symptoms of hyperglycemia.…”

Section: Drugs For Prediabetes Treatmentmentioning

confidence: 99%

Metabolic disorders in prediabetes: From mechanisms to therapeutic management

Ping,

Hu,

et al. 2024

World J Diabetes

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Diabetes, one of the world's top ten diseases, is known for its high mortality and complication rates and low cure rate. Prediabetes precedes the onset of diabetes, during which effective treatment can reduce diabetes risk. Prediabetes risk factors include high-calorie and high-fat diets, sedentary lifestyles, and stress. Consequences may include considerable damage to vital organs, including the retina, liver, and kidneys. Interventions for treating prediabetes include a healthy lifestyle diet and pharmacological treatments. However, while these options are effective in the short term, they may fail due to the difficulty of long-term implementation. Medications may also be used to treat prediabetes. This review examines prediabetic treatments, particularly metformin, glucagon-like peptide-1 receptor agonists, sodium glucose cotransporter 2 inhibitors, vitamin D, and herbal medicines. Given the remarkable impact of prediabetes on the progression of diabetes mellitus, it is crucial to intervene promptly and effectively to regulate prediabetes. However, the current body of research on prediabetes is limited, and there is considerable confusion surrounding clinically relevant medications. This paper aims to provide a comprehensive summary of the pathogenesis of pre-diabetes mellitus and its associated therapeutic drugs. The ultimate goal is to facilitate the clinical utilization of medications and achieve efficient and timely control of diabetes mellitus.

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Protective Effects of Lycium barbarum Polysaccharides, Mulberry Leaf Flavonoids, and Ginkgo Leaf Flavonoids on HBZY-1 Cell Injury: An Investigation of Lactate Dehydrogenase and Total Nitric Oxide Synthase

Liu,

Fu,

Cao

2024

sci adv mater

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The impacts of natural plant extracts, including Lycium barbarum polysaccharides (LBP), mulberry leaf flavonoids (MLF), and ginkgo leaf flavonoids (GLF), on high glucose (HG)-induced injury in HBZY-1 mesangial cells were analyzed. LBP, MLF, and GLF were individually extracted, and their purities were determined. HBZY-1 cells cultured in low glucose (LG) served as the Normal group (NG), while HG culture represented the HG group. Subsequently, HBZY-1 cells in the HG group were treated with 300 μg/mL of LBP, MLF, and GLF, resulting in the HG+LBP, HG+MLF, and HG+GLF groups, respectively. Cell viability (CV) was assessed using the MTT assay, and cellular morphological changes were observed through HE staining. Meanwhile, lactate dehydrogenase (LDH) and nitric oxide (NO) levels were examined using the microplate method. Furthermore, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels were detected by ELISA. mRNA levels in IL-6, IL-1β, and TNF-α were assessed using real-time quantitative polymerase chain reaction (rt-qPCR), and Collagen IV was examined using immunofluorescence. The results revealed that the polysaccharide content in the LBP extract was 63.57%, the flavonoid contents in the MLF and GLF extracts were 55.40% and 48.62%, respectively. Based on the NG group, HG group exhibited decreased CV, increased LDH and MDA, decreased NO, SOD, and GSH-Px, elevated mRNA levels in IL-6, IL-1β, and TNF-α, and reduced Collagen IV, showing great differences (P < 0.05). Based on the HG group, the HG+LBP, HG+MLF, and HG+GLF groups demonstrated increased CV, decreased LDH and MDA levels, increased NO, SOD, and GSH-Px levels, decreased mRNA levels in IL-6, IL-1β, and TNF-α, and increased Collagen IV, presenting obvious differences (P < 0.05). Comparing to the HG+LBP group, the HG+MLF and HG+GLF groups exhibited enhanced CV, downshifted LDH and MDA, elevated NO, SOD, and GSH-Px, downregulated mRNA in IL-6, IL-1β, and TNF-α, and increased Collagen IV (P < 0.05). No significant changes in CV, LDH, MDA, NO, SOD, GSH-Px, IL-6, IL-1β, TNF-α, or Collagen IV were observed in the HG+MLF and HG+GLF groups to the NG group (P >0.05). In conclusion, natural plant extracts such as LBP, MLF, and GLF exerted protective effects against injury in HBZY-1 mesangial cells caused by HG and possessed significant anti-inflammatory, antioxidant stress, and antifibrotic damage properties.

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The anti-obesity effect of mulberry leaf (Mori Folium) extracts was increased by bioconversion with Pectinex

Cited by 3 publications

References 68 publications

Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice

Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice

Metabolic disorders in prediabetes: From mechanisms to therapeutic management

Protective Effects of Lycium barbarum Polysaccharides, Mulberry Leaf Flavonoids, and Ginkgo Leaf Flavonoids on HBZY-1 Cell Injury: An Investigation of Lactate Dehydrogenase and Total Nitric Oxide Synthase

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