Interactions and mechanisms of phenolic compounds with human immunodeficiency virus-1 Tat protein
Cherry May S. Delos Santos,
June Alexis A. Santos,
Danilet Vi M. Mendoza
Abstract:Human immunodeficiency virus remains a serious health threat, with an increase of 24% newly cases globally. Targeting Tat protein is an emerging therapeutic strategy for inhibiting the feedback loop that drives the exponential increase in viral transcription and particle production of the virus. The study aimed to determine the inhibitory potential of phenolic compounds from Ricinus communis L. and Jatropha curcas L., against the Tat C protein using in silico techniques. Phenolic compounds identified from both… Show more
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