Near infra-red polymeric nanoparticle based optical imaging in Cancer diagnosis

Perumal, Venkatesan; Sivakumar, Ponnurengam Malliappan; Zarrabi, Ali; Saravanan, Muthupandian; Vijayaraghavalu, Sivakumar; Sahoo, Kaustuv; Das, Amlan; Das, Soumen; Payyappilly, Sanal Sebastian; Das, Subhasish

doi:10.1016/j.jphotobiol.2019.111630

Cited by 45 publications

(20 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymeric NPs can satisfy several requirements, which allow clinical applications for drug delivery or gene therapy in cancer to be reached [ 77 , 101 , 102 ], as well as for delivering diagnostic probes [ 103 ]. Optical imaging tools were obtained by engineering polymeric fluorescent NPs in order to detect cancer margins.…”

Section: Polymeric Nps As Diagnostic Tools and Therapeutic Nanocarriers In Pediatric Brain Malignanciesmentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

View full text Add to dashboard Cite

Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood–brain barrier. In this review we will discuss the developments of nanoparticle-based strategies as novel precision nanomedicine tools for diagnosis and therapy in pediatric brain cancers, with a particular focus on targeting strategies to overcome the main physiological obstacles that are represented by blood–brain barrier.

show abstract

Section: Polymeric Nps As Diagnostic Tools and Therapeutic Nanocarriers In Pediatric Brain Malignanciesmentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The necessity to improve the accuracy and reliability of early diagnosis of cancer has led to a rapid increase not only in investigating the clinical use of nanotechnology tools, techniques, and systems for cancer screening [ 21 ] but also in using nanomaterials as biosensors for the detection of cancer biomarkers in bodily fluids [ 22 ]. The benefit of using nanotechnology for cancer diagnosis lies in the high complexity and multifactorial nature of the disease that originate from cellular abnormalities in genetic and molecular processes [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine

Canetta

2021

IJMS

View full text Add to dashboard Cite

Raman scattering is one of the most used spectroscopy and imaging techniques in cancer nanomedicine due to its high spatial resolution, high chemical specificity, and multiplexity modalities. The flexibility of Raman techniques has led, in the past few years, to the rapid development of Raman spectroscopy and imaging for nanodiagnostics, nanotherapy, and nanotheranostics. This review focuses on the applications of spontaneous Raman spectroscopy and bioimaging to cancer nanotheranostics and their coupling to a variety of diagnostic/therapy methods to create nanoparticle-free theranostic systems for cancer diagnostics and therapy. Recent implementations of confocal Raman spectroscopy that led to the development of platforms for monitoring the therapeutic effects of anticancer drugs in vitro and in vivo are also reviewed. Another Raman technique that is largely employed in cancer nanomedicine, due to its ability to enhance the Raman signal, is surface-enhanced Raman spectroscopy (SERS). This review also explores the applications of the different types of SERS, such as SERRS and SORS, to cancer diagnosis through SERS nanoprobes and the detection of small-size biomarkers, such as exosomes. SERS cancer immunotherapy and immuno-SERS (iSERS) microscopy are reviewed.

show abstract

“…On the one hand, their organic nature allows for the fine-tuning of specific properties by molecular engineering, including morphological, , photophysical, , colloidal, and surface , properties. On the other hand, nanoparticles (NPs) have had valuable developments in numerous biomedical fields that can benefit from 2P advantages, ranging from diagnosis to photodynamic therapy to localized photorelease of active molecules to image guided surgery . In addition, nanoparticles are typically brighter than molecular dyes as long as their fluorescence is maintained.…”

Section: Introductionmentioning

confidence: 99%

Ultrabright Red to NIR Emitting Fluorescent Organic Nanoparticles Made from Quadrupolar Dyes with Giant Two-Photon Absorption (2PA) in the NIR Region. Confinement Effect on Fluorescence and 2PA and Tuning of Surface Properties

et al. 2021

View full text Add to dashboard Cite

Fluorescent Organic Nanoparticles (FONs) are light-emitting, molecular-based nanoparticles that can be obtained from the nanoprecipitation of dedicated hydrophobic organic dyes in water. They represent a versatile family of water-soluble fluorescent nanotools whose luminescent properties can be tuned by bottom-up molecular engineering of their composing dyes. We recently reported on a quadrupolar red-emitting dye that yields spontaneously stealthy bare FONs which do not require coating to hinder interactions with cell membranes. Its quadrupolar design also hints to the possibility that it may be a strong two-photon absorber for bioimaging purposes. In this paper, we further investigate the two-photon absorption (2PA) of this dye and resulting FONs and report on a structure-related series of extended dyes engineered to yield NIR-emitting FONs. All dyes lead to stable, small (12–20 nm in diameter), and bright FONs. The experimental study reveals that molecular confinement strongly influences the fluorescence and 2PA properties of these dyes depending on the nature of the π-extended system. As expected, extension of the π-conjugated system induces a red-shift of the absorption and emission bands as well as an increase and spectral broadening of the 2PA responses in solution. Upon aggregation of the dyes within nanoparticles, a reduction of the fluorescence quantum yield is observed whose amplitude depends strongly on the nature of the π-conjugated systems. Interestingly, the peak 2PA cross sections increase upon confinement of the shortest dye, while a spectral broadening and slight red shift of the 2PA bands of the most extended dyes is observed. Taken together, these properties allow the most extended dye to yield very bright NIR-emitting FONs (εmaxΦ = 7 × 106 M–1 cm–1, σ2 maxΦ = 4 × 105 GM). Interestingly, the nature of the π-conjugated system was also found to modulate the stealthiness of the resulting nanoparticles toward biological membranes. As a result, by fine-tuning the molecular design of the quadrupolar FON-composing dyes, we achieved NIR-absorbing, NIR-emitting, spontaneously stealthy small nanoparticles having record one- and two-photon brightness. Finally, we demonstrate that these FONs can be noncovalently surface-coated with a polycationic polymer, thanks to their highly negative surface potentials. This induces a reversal of their surface potential which in turn triggers their internalization within cells.

show abstract

Near infra-red polymeric nanoparticle based optical imaging in Cancer diagnosis

Cited by 45 publications

References 84 publications

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine

Ultrabright Red to NIR Emitting Fluorescent Organic Nanoparticles Made from Quadrupolar Dyes with Giant Two-Photon Absorption (2PA) in the NIR Region. Confinement Effect on Fluorescence and 2PA and Tuning of Surface Properties

Contact Info

Product

Resources

About