Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine

Canetta, Elisabetta

doi:10.3390/ijms222313141

Cited by 18 publications

(15 citation statements)

References 99 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This review is not intended to provide a comprehensive list of imaging labels and NPs for image-guided therapy. Promising new imaging labels—such as 19F for MRI [ 177 ]; new imaging modalities such as magnetic particle imaging (MPI) [ 178 ] and Ramen spectroscopy [ 179 ]; as well as emerging biologic/biomimetic NPs, such as extracellular vehicles [ 180 ], the iron-storage protein Ferritin [ 181 ], and cell membrane-based NPs [ 182 ]—have recently entered the arena and are likely be added to the toolbox for cancer nanotheranostics. It can be envisioned that the explosive development of NPs in recent years will continue.…”

Section: Discussionmentioning

confidence: 99%

Nanotheranostics for Image-Guided Cancer Treatment

et al. 2022

View full text Add to dashboard Cite

Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanotheranostics for Image-Guided Cancer Treatment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Theranostic approaches have been primarily introduced and developed for early-stage detection and prevention of complex diseases that impose a significant economic and emotional burden on the patient population. According to the World Health Organization (WHO), cancer is a leading cause of death and a report by GLOBOCAN2020 indicates that the socioeconomic burden generated by cancer is expected to be shared by 28.4 million patients globally by 2040 2 , 3 . A diagnostic test combined with an appropriate therapy may allow clinicians to modify the treatment plan based on real-time diagnostic data, making it more suited to the patients being studied 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

show abstract

“…It can effectively eliminate the signal interference outside the focal plane, and its properties such as the spatial resolution, signal-to-noise ratio, and accuracy are all higher than that of the ordinary Raman spectroscopy [25]. The position, intensity, and line width of Raman spectra can provide information on the vibration and rotation of sample molecules; Confocal Raman spectroscopy technology can realize the "fingerprint identification" of the changes of certain chemical bonds and functional groups in the biomacromolecules caused by the interaction between drugs and biomolecules [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

The Mechanism of Dynamic Interaction between Doxorubicin and Calf Thymus DNA at the Single-Molecule Level Based on Confocal Raman Spectroscopy

et al. 2022

View full text Add to dashboard Cite

It is of great fundamental significance and practical application to understand the binding sites and dynamic process of the interaction between doxorubicin (DOX) and DNA molecules. Based on the Confocal Raman spectroscopy, the interaction between DOX and calf thymus DNA has been systemically investigated, and some meaningful findings have been found. DOX molecules can not only interact with all four bases of DNA molecules, i.e., adenine, thymine, cytosine, guanine, and phosphate, but also affect the DNA conformation. Meanwhile, the binding site of DOX and its derivatives such as daunorubicin and epirubicin is certain. Furthermore, the interaction between DOX and DNA molecules is a dynamic process since the intensities of each characteristic peaks of the base, e.g., adenine, cytosine, and phosphate, are all regularly changed with the interaction time. Finally, a dynamic mechanism model of the interaction between DOX and DNA molecules is proposed; that is, there are two kinds of interaction between DOX and DNA molecules: DOX-DNA acts to form a complex, and DOX-DOX acts to form a multimer. The two effects are competitive, as the former compresses DNA molecules, and the latter decompresses these DNA molecules. This work is helpful for accurately understanding and developing new drugs and pathways to improve and treat DOX-induced cytotoxicity and cardiotoxicity.

show abstract

Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine

Cited by 18 publications

References 99 publications

Nanotheranostics for Image-Guided Cancer Treatment

Nanotheranostics for Image-Guided Cancer Treatment

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

The Mechanism of Dynamic Interaction between Doxorubicin and Calf Thymus DNA at the Single-Molecule Level Based on Confocal Raman Spectroscopy

Contact Info

Product

Resources

About