Nature of Histamine Receptors Concerned in Capillary Permeability

Abstract

1Histamine and 2-methyl-histamine (H,-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase.2 Mepyramine (HI-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3 Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4 The results indicate involvement of the HI-receptors in histamine-induced increase in capillary permeability.

A report on anti-oedemogenic activity of Byttneria herbacea roots – Possible involvement of histamine receptor (type I)

“…Accordingly, histamine induced peritoneal vascular permeability was performed where HBH (in dose dependant manner) and mizolastine significantly inhibited this response of histamine. Further, according to Whittle (1964), acetic acid induced writhing response is primarily caused by increased capillary permeability which is reported to be solely mediated by H1 receptors (Bhargava et al, 1977;Owen et al, 1980). HBH was also observed to inhibit such writhing response in a significant and dose-dependent manner.…”

“…Following the administration of carrageenan and histamine the paw volumes were measured up to 5th hour using method of Bhatt et al (1977). Histamine induced vascular permeability was performed in mice (Bhargava et al, 1977). Mizolastine (10 mg/kg) and HBH were administered orally, 30 min prior to the administration of histamine (i.p., 10 g).…”

Microvascular Protein Efflux: Interaction of Histamine and H1 Receptors

“…(12) have recently reported that the histamine-induced increase in capillary permeability of peritoneal blood vessels of mice could be blocked with an H, receptor antagonist, mepyramine, but not with burimamide, an H2 receptor antagonist. Further, a combination of mepyramine and burimamide did not offer any greater protection than mepyramine alone.…”

Antiinflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles.

“…Assay of mediators in the inflammatory exudate produced by carrageenin in the rat showed the release of both histamine and bradykinin in the early phase, but that of prostaglandin E2 only after two to three hours (29)(30)(31)(32)(33).…”

“…It is well-known that the edema induced by carrageenin and the increase of vascular permeability induced by acetic acid are in volved in the early exudative stage of inflam mation, one of the important processes of inflammatory pathology (26)(27)(28)(29)(30)(31)(32)(33). Myristicin inhibited the edema induced by carraggeenin and the increase of the vascular permeability induced by acetic acid, showing that it exerts the antiinflammatory effect at the early exudative stage of inflammation.…”