Abstract:The effects of HI and H, receptor antagonists on histamine-induced increase in microvascular protein transport was examined in the dog forelimb and horse digit. Local intraarterial infusion of histamine (4 pglmin of the base) produces marked increases in lymph flow, lymph protein concentration, and the estimated permeability -surface area (PS) ratio in both the limb and digit (3). These increases were completely prevented in the horse digit by local administration of the H, antagonist, tripelennamine, and in t… Show more
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