Natural and synthetic substances related to human health (IUPAC Technical Report)

Topliss, John G.; Am, Clark; Ernst, Edzard; Hufford, Charles D.; Johnston, G. A. R.; Rimoldi, John M.; Weimann, Boris

doi:10.1351/pac200274101957

Cited by 62 publications

(27 citation statements)

References 62 publications

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“…Now a day, long term prevention of CVD are associated with healthy diet rich in fresh fruits, vegetables or plants rich in antioxidants. Hence tremendous increase in research regarding finding a natural product which is probably superior in terms of safety and efficacy in contrast to different synthetic analogues 9 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cardioprotective Activity of Fulvic Acid Against Isoproterenol Induced Oxidative Damage in Rat Myocardium

Shikalgar¹,

Naikwade²

2018

Int. Res. J. Pharm.

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The aim of study was to evaluate cardio protective activity of fulvic acid in Isoprenaline induced cardiac toxicity. In current investigation, female/male wistar rats were divided into five groups, normal, control, Fulvic acid 100mg/kg, Fulvic acid 200mg/kg, and Fulvic acid 300 mg/kg. Isoprenaline 85 mg/kg was administered on 29 th and 30 th day during study period to all except normal group. Fulvic acid was administered to respective groups once daily for total 30 days, on the last day of study, the animals were anesthetized to record ECG and BP (by cannulating carotid artery), blood was collected from carotid artery and SGOT, LDH And CK-MB were estimated, Animals were sacrificed to isolate heart and preparation of tissue homogenate. The antioxidant status is analyzed by measuring MDA content, SOD CAT, GSH activity. The tissue sample is also preserved for histological studies. Isoprenaline causes cardiac damage which was manifested by alteration in serum cardiac markers, antioxidant markers, ECG and hemodynamic and histological changes. These alterations were restored due to treatment with fulvic acid 300mg/kg. With data obtained in study it have been concluded that fulvic acid treatment for 4 weeks protect the heart of rat from cardiotoxicity as a result of isoprenaline administration.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cardioprotective Activity of Fulvic Acid Against Isoproterenol Induced Oxidative Damage in Rat Myocardium

Shikalgar¹,

Naikwade²

2018

Int. Res. J. Pharm.

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“…Highest activity was revealed by halogenated monoesters (12)(13)(14)(15)(16)(17)(18)(19)(20) in general and iodinated monoesters in particular (18)(19)(20). Monoesters having substituents linked through oxygen to benzene ring (1)(2)(3)(4)(5)(6)(7)(8) and (24-29) displayed relatively less activity as compared to halogenated monoesters. This could be explained on the basis that the presence of halogens could be responsible for enhanced activity.…”

Section: Resultsmentioning

confidence: 99%

“…At present evaluation of synthetic compounds for their antifungal and antibacterial activity is the subject of active chemistry research [1][2][3]. In spite of the fact diseases caused by microbes are increasing with the passage of time, the microbes have become resistant to the available drugs and hence posing a great threat to human being but no considerable antifungal and antibacterial drugs have been synthesised/discovered from the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Iqbal¹,

Baloch²,

Baloch³

2014

Bull. Chem. Soc. Eth.

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ABSTRACT. Monoester of succinic acid (1-29), synthesised and characterised at our laboratory, were investigated with reference to their antifungal and antibacterial activities. The results concluded that though almost all the compounds were bioactive but the degree of activity was dependent over the substituent attached to benzyl group and order of their bioactivity was iodo > chloro > methoxy > nitro substituted monoesters against the considered microbes.

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“…sunlight, nutrient availability, temperature, etc.) can affect carbon uptake and hence the synthesis and utilization of secondary chemicals in plant species (Topliss et al 2004;Ziska et al 2005). Given the universal importance of opiates on human health (for good or ill), how will recent and projected changes in atmospheric carbon dioxide alter their concentration and/or production?…”

Section: Discussionmentioning

confidence: 99%

Recent and projected increases in atmospheric carbon dioxide and the potential impacts on growth and alkaloid production in wild poppy (Papaver setigerum DC.)

2008

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In the current study, we quantified changes in the growth and alkaloid content of wild poppy, (Papaver setigerum) as a function of recent and projected changes in global atmospheric carbon dioxide concentration, [CO 2 ]. The experimental [CO 2 ] values (300, 400, 500 and 600μmol mol −1 ) correspond roughly to the concentrations that existed during the middle of the twentieth century, the current concentration, and near and long-term projections for the current century (2050 and 2090), respectively. Additional carbon dioxide resulted in significant increases in leaf area and above ground biomass for P. setigerum at all [CO 2 ] relative to the 300μmol mol −1 baseline. Reproductively, increasing [CO 2 ] from 300 to 600μmol mol −1 increased the number of capsules, capsule weight and latex production by 3.6, 3.0 and 3.7×, respectively, on a per plant basis. Quantification of secondary compounds (i.e. those not involved in primary metabolism) included the alkaloids morphine, codeine, papaverine and noscapine. The amount of all alkaloids increased significantly on a per plant basis, with the greatest relative increase occurring with recent increases in atmospheric carbon dioxide (e.g. from 300 to 400μmol mol −1 ). Overall, these data suggest that as atmospheric [CO 2 ] continues to increase, significant effects on the production of secondary plant compounds of pharmacological interest (i.e. opiates) could be expected.

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Natural and synthetic substances related to human health (IUPAC Technical Report)

Cited by 62 publications

References 62 publications

Evaluation of Cardioprotective Activity of Fulvic Acid Against Isoproterenol Induced Oxidative Damage in Rat Myocardium

Evaluation of Cardioprotective Activity of Fulvic Acid Against Isoproterenol Induced Oxidative Damage in Rat Myocardium

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Recent and projected increases in atmospheric carbon dioxide and the potential impacts on growth and alkaloid production in wild poppy (Papaver setigerum DC.)

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