Tumor-promoting characteristics of seven esters, 1 -7, obtained from the latex of Euphorbia cauducifolia L. was appraised by carrying out NMRI mice back skin. The structures of 1 -7 were elucidated by spectroscopic techniques like 1 H-and (7). Compounds 1 -4 were isolated for the first time, whereas 5 -7 are known metabolites but detected for the first time in this plant. Biological investigations revealed that these compounds are tumor promoters.
Terpenes U 0200 Bio-active Compounds from Euphorbia cornigera Boiss. -Eight new ingenol derivatives like (I) are isolated from the roots and tested for their molluscicidal activity. Most of these compounds are 1.3-2.2 times more toxic than bayluscide. -(BALOCH, I. B.; BALOCH*, M. K.; BALOCH, A. K.; Eur. J. Med. Chem. 44 (2009) 8, 3188-3194; Dep. Chem., Gomal Univ., Dera Ismail Khan, Pak.; Eng.) -R. Langenstrassen 39-182
Fungi and bacteria are a great threat to all living organisms by causing illnesses in them. Rate of spreading diseases by them is higher in contrast to synthesis of drugs that are antifungal and/or antibacterial 1-4. At present substantial part of the research in chemistry is devoted to the synthesis and characterization of biologically active compounds that would be used against the microbes 5-16. Monoesters of succinic acid, in addition to their chemical uses, possess medicinal properties like, antiHIV, antitumor, antiseptic, antioxidant, antifungal and antibacterial 10-16 activities. In continuation to our work to establish medicinal use of monoesters 17-20 twentyseven (1-27) new monoesters were prepared from succinic anhydride 7 and explored for antifungal and antibacterial activity. All the reported compounds displayed considerable bioactivities. However, the halogenated esters displayed activity equivalent to standard drugs chloramphenicol and ketoconazole. EXPERIMENTAL The microbes used for bioactivities of synthesized compounds (1-27) were Candida albicans ATCC 10231 (C. albicans), Aspergillus niger F2723 (A. niger), Escherichia coli MTCC-739 (E. coli) and Proteus mirabilis ATCC 14153 (P. mirabilis). Ketoconazole purchased from M/s SMS Pharmaceuticals Ltd. Hyderabad and chloramphenicol from Sigma St. Louis, USA was used as standard.
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