Anti-tumor 12-deoxyphorbol esters from Euphorbia cornigera

Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax

“…Recently, the Euphorbiaceae antitumoral properties have been demonstrated to produce in vitro cytotoxicity (Tanaka et al, 2006;Luo and Wang, 2006;Baloch et al, 2008). In this sense, Baloch et al (2008) demonstrated that 12-deoxyphorbol ester from Euphorbia cornigera has an important inhibitory activity on the growth and viability of KB cells.…”

“…In this sense, Baloch et al (2008) demonstrated that 12-deoxyphorbol ester from Euphorbia cornigera has an important inhibitory activity on the growth and viability of KB cells. Luo and Wang (2006) documented that the anti-proliferative effect of jolkinolide B, a diterpene isolated from Euphorbia fischeriana Steud, on K-562 cells is achieved by arresting the cell cycle in the G1 phase and subsequently inducing apoptosis.…”

Irritant and co-carcinogenic diterpene esters from the latex of Euphorbia cauducifolia L.

“…The active portion of the material was identified by testing against mouse ear. The selected crude was subjected to HPLC to get pure compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

“…Therefore, these aspects prompted us to investigate its biologically active constituents. In previous studies, we reported biologically active compounds from the latex [8,9]. In the present investigation, 10 compounds (1-10) were isolated and their structures were elucidated (Figure 1), and their biological activity was assessed.…”

Isolation and Structure Elucidation of Diterpenes from Euphorbia pannonica, E. esula and E. falcata

“…The mechanisms of their action in the inhibition of DNA synthesis were also investigated and a significant correlation was found between the cytotoxicity and DNA cross-link and DNA strand-break formation. 113 The levels of in vitro cytotoxicity of 2 ingenol derivatives isolated specific, as it has no effect on the platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor 1 signalling pathways. angelate in the treatment of human cancer.…”