Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax

Nogueira, Iara Antonia Lustosa; Leão, Aryane B.B.; Vieira, Marcelo de Sousa; Benfica, Polyana Lopes; Cunha, Luíz Carlos da; Valadares, Marize Campos

doi:10.1016/j.jep.2008.08.026

Cited by 34 publications

(24 citation statements)

References 23 publications

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“…The positive control (Figures 2c and 2d) and the treatments using S. umbellatum latex Because of the immense flora existing all over the world along with cultural aspects, the use of plants in the form of crude extracts, infusions, or plasters has been revived as a usual practice to treat common diseases (Marques and Farah, 2009). Nogueira et al (2008) have already investigated the pharmacological actions of the ethanolic crude extract of aerial parts of S. umbellatum and confirmed the an- (Figures 2g and 2h) presented a relevant increase in vascular net as well as infiltrated inflammatory cells (Figure 3 -detail of Figure 2h). …”

Section: Discussionmentioning

confidence: 99%

“…The latex of this plant is used against various diseases such as diabetes mellitus, Hansen´s disease, tripanosomiases, leukemia, and several malignant tumors (Ortêncio, 1997). The mutagenic, cytotoxic, antitumoral and antiangiogenic action of the leaves of this plant have been already identified (Valadares et al, 2007;Nogueira et al, 2008). In folk medicine, the latex of plants belonging to the genus Synadenium has been considered caustic and toxic.…”

Section: Introductionmentioning

confidence: 99%

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Angiogenic activity of Synadenium umbellatum Pax latex

Melo-Reis

Silva³

et al. 2010

Braz. J. Biol.

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Synadenium umbellatum Pax, popularly known as "cola-nota", is a medicinal plant that grows in tropical regions. Latex of this plant is used to treat various diseases such as diabetes mellitus, Hansen´s disease, tripanosomiases, leukemia and several malignant tumors. In the present study, the angiogenic activity of S. umbellatum latex was evaluated using the chick embryo chorioallantoic membrane (CAM) assay. Results showed significant increase of the vascular net (p < 0.05) compared to the negative control (H 2 O). The histological analysis was in accordance with the results obtained. In conclusion, our data indicate that S. umbellatum latex, under the conditions of this research, presented angiogenic effect.Keywords: Angiogenesis, latex, chick chorioallantoic membrane, Synadenium umbellatum. Atividade angiogênica do látex de Synadenium umbellatum Pax ResumoSynadenium umbellatum Pax, popularmente conhecida como "cola-nota", é uma planta medicinal que cresce em regiões tropicais. O látex desta planta tem sido utilizado no tratamento de várias doenças, como diabetes mellitus, hanseníase, tripanossomíases, leucemia e vários tumores malignos. No presente estudo, a atividade angiogênica do látex de S. umbellatum foi avaliada pelo ensaio da membrana corio-alantóide (MCA) de ovo embrionado de galinha. Os resultados mostraram aumento significativo da rede vascular (p < 0.05) em relação ao controle negativo (H 2 O). A análise histológica está em concordância com os resultados obtidos. Em conclusão, os dados indicaram que, nas condições experimentais deste estudo, o látex de S. umbellatum exibiu efeito angiogênico.Palavras-chave: Angiogênese, látex, membrana corio-alantóide de galinha, Synadenium umbellatum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiogenic activity of Synadenium umbellatum Pax latex

Melo-Reis

Silva³

et al. 2010

Braz. J. Biol.

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“…Nogueira et al, (2008) demonstrated that the ethanol extract of the leaves of Synadenium umbellatum is an effective antitumoural agent and in vivo it presents an antiangiogenic effect. Chloroform extract of the leaves of Synadenium grantii was recently found (Hassan et al, 2012) to have cytotoxic activity in human lung fibroblast strain.…”

Section: Introductionmentioning

confidence: 99%

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Oliveira¹,

Munhoz²,

Lemes³

et al. 2013

Journal of Ethnopharmacology

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“…The Synadenium genus contains nineteen species, and is a small genus of the Euphorbiaceae family (Kinghorn, 1980). Several species of this genus have been pharmacologically evaluated against anti-infl ammatory, antitumor, analgesic, immune-regulatory and fi brinolytic experimental models (Premaratna et al, 1981;Jager, 1996;Rajesh et al, 2006;Valadares et al, 2007;Nogueira et al, 2008). Cunha et al (2009) also evaluated the toxicity of Synadenium.…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax

Cited by 34 publications

References 23 publications

Angiogenic activity of Synadenium umbellatum Pax latex

Angiogenic activity of Synadenium umbellatum Pax latex

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Anti-ulcer activity of Synadenium grantii latex

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