Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Iqbal, Muhammad; Baloch, Imam Bakhsh; Baloch, Musa Kaleem

doi:10.4314/bcse.v28i1.15

Bull. Chem. Soc. Eth.

2014

DOI: 10.4314/bcse.v28i1.15

|View full text |Cite

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Muhammad Iqbal¹,

Imam Bakhsh Baloch²,

Musa Kaleem Baloch³

Abstract: ABSTRACT. Monoester of succinic acid (1-29), synthesised and characterised at our laboratory, were investigated with reference to their antifungal and antibacterial activities. The results concluded that though almost all the compounds were bioactive but the degree of activity was dependent over the substituent attached to benzyl group and order of their bioactivity was iodo > chloro > methoxy > nitro substituted monoesters against the considered microbes.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2014

2020

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained mixture was subjected to separation on column chromatography using mixture of n-hexane-ethyl acetate (1:0 → 0:1) to get thirty fractions . The fractions (17)(18)(19)(20)(21)(22) were combined and re-chromatographed on preparative thin layer chromatography using n-hexane-ethyl acetate mixture (4:6) as an eluent which yielded colourless amorphous solid pure compounds . Recording UV, IR, 1 H NMR and 13 C-NMR, analysis and mass measurement, characterized the target substrates 7 .…”

mentioning

confidence: 99%

Antimicrobial Activities of Monoesters of Succinic Acid

Iqbal¹,

Iqbal²,

Bılal³

et al. 2014

Asian J. Chem.

View full text Add to dashboard Cite

Fungi and bacteria are a great threat to all living organisms by causing illnesses in them. Rate of spreading diseases by them is higher in contrast to synthesis of drugs that are antifungal and/or antibacterial 1-4. At present substantial part of the research in chemistry is devoted to the synthesis and characterization of biologically active compounds that would be used against the microbes 5-16. Monoesters of succinic acid, in addition to their chemical uses, possess medicinal properties like, antiHIV, antitumor, antiseptic, antioxidant, antifungal and antibacterial 10-16 activities. In continuation to our work to establish medicinal use of monoesters 17-20 twentyseven (1-27) new monoesters were prepared from succinic anhydride 7 and explored for antifungal and antibacterial activity. All the reported compounds displayed considerable bioactivities. However, the halogenated esters displayed activity equivalent to standard drugs chloramphenicol and ketoconazole. EXPERIMENTAL The microbes used for bioactivities of synthesized compounds (1-27) were Candida albicans ATCC 10231 (C. albicans), Aspergillus niger F2723 (A. niger), Escherichia coli MTCC-739 (E. coli) and Proteus mirabilis ATCC 14153 (P. mirabilis). Ketoconazole purchased from M/s SMS Pharmaceuticals Ltd. Hyderabad and chloramphenicol from Sigma St. Louis, USA was used as standard.

show abstract

mentioning

confidence: 99%

Antimicrobial Activities of Monoesters of Succinic Acid

Iqbal¹,

Iqbal²,

Bılal³

et al. 2014

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis

Damrongrungruang

Panpitakkul

Somudorn

et al. 2020

CDD

View full text Add to dashboard Cite

Background: Glutaryl melatonin, which is synthesized from melatonin and is a pineal glandderived neurohormone with anti-inflammatory and anti-oxidant properties, was comparatively investigated for its potential use as a topical anti-inflammatory agent. Objective: Glutaryl melatonin, synthesized and screened for in vitro anti-candidiasis and in vitro and in vivo anti-inflammatory activities, was formulated as a niosome gel for topical oral evaluation in 5- fluorouracil-induced oral mucositis in mice. Methods: In vitro anti-fungal activity in Candida albicans, in vitro anti-inflammatory activity in Escherichia coli liposaccharide-induced RAW cells and in vivo anti-inflammatory activity using a croton oilinduced ear edema model in ICR mice were investigated. Mucositis in mice (n= 6/group, 10-week-old mice) was induced by intraperitoneal injections of 5-fluorouracil, and the mice were subjected to a topical oral application of niosome gel containing melatonin (2% w/w) or glutaryl melatonin (2% w/w) and were compared with mice subjected to blank, fluocinolone acetonide (0.5% w/w) and control conditions. Results: Glutaryl melatonin, at a 14.2 mM concentration, showed the highest fungicidal effect on C. albicans using the broth dilution method, indicating a nonsignificant difference from 1 μM of nystatin (p = 0.05). Nitric oxide, interleukin-6 and tumor necrosis factors were analyzed by ELISA. Liposaccharide-induced RAW cells were significantly reduced by glutaryl melatonin (p < 0.01). Ear edema inhibition of glutaryl melatonin was significant 1 h after application compared with that of melatonin (p = 0.03). Food consumption and body weight of the 5-fluorouracil-treated mice were significantly lower than those of the normal mice before all treatments (p < 0.05). Differences in the amount of licking behavior, which were observed in the control group for 5 min, were noticeable in the 5- fluorouracil-treated mice but not in the mice treated with the glutaryl melatonin niosome gel. Conclusion: Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties. The incorporation of glutaryl melatonin in a niosome gel formulation, demonstrated the potential for topical oral applications to reduce oral discomfort caused by 5-fluorouracil treatment in mice.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Cited by 2 publications

References 18 publications

Antimicrobial Activities of Monoesters of Succinic Acid

Antimicrobial Activities of Monoesters of Succinic Acid

Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis

Contact Info

Product

Resources

About