Nasopharyngeal Carcinoma in Children and Adolescents Successful Role of Retrieval Therapy

Zaghloul, Mohamed S.; Dahaba, Nader; Wahab, Amina Abdel; Hussein, Mohamed H.; El-Koutbey, Montasser

doi:10.1177/030089169307900209

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…Although a high proportion of patients in this study presented with undifferentiated carcinomas and locore- gionally advanced disease, locoregional tumoral response rate and survival were comparable to other studies [8][9][10][11][12][13][14][15]17,18,20,28,35,40]. Advanced T-stage and lower radiation doses predicted locoregional tumoral failure, whereas advanced N-stage and exclusion of chemotherapy predicted systemic failure.…”

Section: Discussionsupporting

confidence: 73%

Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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Section: Discussionsupporting

confidence: 73%

Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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Section: Discussionsupporting

confidence: 73%

“…Most of the studies dealing with children and adolescents with nasopharyngeal carcinoma have followed the guidelines determined for adults for prescription of radiation doses [5,10,13,15,40,43]. Improved locoregional tumoral response rates have been achieved with radiation doses in the range of 60-70 Gy [5,10,15].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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Background This study reviews the authors' experience from 1979 through 1996 in the management and outcome of 56 patients with nasopharyngeal carcinoma who were under 20 years of age. Procedure There were 33 males and 23 females, their ages ranging from 7 to 19 years (median: 16 years). Forty patients had World Health Organization type III carcinomas, 16 had T4 tumors, 41 had metastatic cervical lymph nodes, and 50 were at stage III or stage IV. Thirty‐two patients were treated with radiation therapy alone and 24 with the addition of chemotherapy. Cumulative radiation dose to the primary tumor ranged from 18 to 70 Gy (median: 66 Gy) and radiation dose to metastatic cervical lymph nodes ranged from 18 to 70 Gy (median: 66 Gy). Results Follow‐up ranged from 0.1 to 16.8 years (mean: 9 years). Locoregional tumoral complete response was achieved in 49 patients. Locoregional tumoral failure was observed in 12 patients and systemic failure in 11. Overall, locoregional failure‐free, metastases‐free, and disease‐free survival rates at 5 years were 49%, 62%, 79%, and 47%, respectively, for the entire group of patients, 42%, 61%, 72%, and 42%, respectively, for patients treated with radiation therapy alone, and 58%, 63%, 87%, and 54%, respectively, for patients treated with the addition of chemotherapy. Advanced T‐stage and lower radiation doses worsened locoregional failure‐free survival, whereas advanced N‐stage and exclusion of chemotherapy worsened metastases‐free survival. Conclusions In children and adolescents with nasopharyngeal carcinoma, radiation therapy alone results in an improved locoregional tumoral response rate and a reduced locoregional tumoral failure rate at higher radiation doses, while the addition of chemotherapy results in a reduced systemic failure rate. Med. Pediatr. Oncol. 31:498–505, 1998. © 1998 Wiley‐Liss, Inc.

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