Nasopharyngeal carcinoma in childhood and adolescence

Mertens, Rolf; Granzen, Bernd; Lassay, Lisa; Gademann, G.; Hess, Clemens F.; Heimann, G.

doi:10.1002/(sici)1097-0142(19970901)80:5<951::aid-cncr18>3.0.co;2-v

Cited by 69 publications

(21 citation statements)

References 38 publications

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“…Overall, the number of patients in each study included in this analysis varied from 11 No patient underwent surgery. As shown in Table 2, all subjects received RT, while 687 (79.4 %) received also CHT.…”

Section: Resultsmentioning

confidence: 99%

“…Type I is characterised by keratin production, while in Type II, there are group of cells with fusiform or oval nucleus and scant cytoplasm; Type IIa shows pleiomorphism, whereas in Type IIb, lymphoid infiltration is prominent. In Type III, undifferentiated round cells with prominent nucleoli are the major cell type [11]. Between the subjects grouped in this review, the large majority (83.1 %) presented with a Type III tumor.…”

Section: Discussionmentioning

confidence: 98%

“…NPC and in particular undifferentiated NPC is known to be a very radiosensitive tumor [4], thus the main treatment strategy for all the cases of locoregional NPC has been high-dose radiotherapy to the nasopharynx and involved lymph nodes of the neck, and a moderate dose of radiation to uninvolved nodes and surrounding tissue. Concerning radiation's dose, doses greater than 65 Gy have been shown to yield a better local control in a few studies [11,18,19], but other reports have not shown any correlation between the dose of radiation, rate of local relapse, and survival time [20][21][22]. Currently, the optimum dose for a secure control of NPC in children is not yet established.…”

Section: Discussionmentioning

confidence: 99%

“…Despite good local tumor control after highdose radiation therapy, treatment in many patients fails due to locoregional or systemic relapse and long-term survival is unsatisfactory. Most relapses occur within the first 2 years (median of 8 months) and more than 50 % of patients who relapse have overt distant metastases [11,18,25]. With exclusive radiotherapy, the 5-year survival rate has been reported as 20-60 % in most series of young patients affected by NPC [18,19,26,27].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Gioacchini

Tulli

Kaleci

et al. 2016

Eur Arch Otorhinolaryngol

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To systematically review and discuss the published data about treatments and outcomes for children and adolescents affected by nasopharyngeal carcinoma. In April 2015, an appropriate string was run on PubMed to retrieve all relevant articles. A cross-check was performed by two of the authors on abstracts and full-text articles found using the selected inclusion and exclusion criteria. A meta-analysis concerning the rate of reported disease-free survival and overall survival was performed. Fifteen studies were identified comprising a total of 865 subjects affected by nasopharyngeal carcinoma. According to the American Joint Committee for Cancer Staging system, the majority of tumors were classified as Stage IV (57.3 %). All included patients underwent radiotherapy, while 687 (79.4 %) received also some regimen of chemotherapy. On the basis of our statistical analysis, the mean (95 % CI) rate of disease-free survival was 66 % (95 % CI 56-76). The mean (95 % CI) rate of the overall survival resulted 68 % (95 % CI 58-78). On the basis of our analysis, it may be affirmed that the prognosis of juvenile nasopharyngeal carcinoma is still unsatisfactory. New reports on homogeneous populations are needed to better define the most influencing prognostic factors and to evaluate the introduction of possible alternative therapeutic protocols.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Gioacchini

Tulli

Kaleci

et al. 2016

Eur Arch Otorhinolaryngol

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show abstract

“…1 Nasopharyngeal carcinoma is far more common in certain areas of Asia and Africa, probably bound to EBV epidemiology, and in North America and Europe it accounts for approximately 1-3% of pediatric malignancies. 2,3 There are not available data of NPC incidence in Argentina, but it does not appear to be different from Europe. The distribution according to age is bimodal, with an early peak of incidence between 10 and 20 years and a second between 40 and 60 years.…”

Section: Discussionmentioning

confidence: 99%