Nasopharyngeal carcinoma in childhood and adolescence

Zubizarreta, Pedro; D'Antonio, Gabriela; Raslawski, Elsa; Gallo, Guillermo; Preciado, María Victoria; Casak, Sandra J.; Scopinaro, Marcelo; Morales, Guillermo; Sackmann‐Muriel, Federico

doi:10.1002/1097-0142(20000801)89:3<690::aid-cncr26>3.0.co;2-s

Cited by 59 publications

(13 citation statements)

References 25 publications

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“…In our study trismus was also reported in four patients. The prevalence of trismus in childhood nasopharyngeal carcinoma ranges from 7 – 27% [12, 36, 37]. Radiation dose to the salivary glands and temporomandibular joint and muscles of mastication are risk factors for xerostomia and trismus.…”

Section: Discussionmentioning

confidence: 99%

Long-term effect of chemotherapy–intensity-modulated radiation therapy (chemo-IMRT) on dentofacial development in head and neck rhabdomyosarcoma patients

Owosho

Brady

Wolden

et al. 2016

Pediatric Hematology and Oncology

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Dentofacial developmental abnormalities have been reported in head and neck rhabdomyosarcoma (HNRMS) patients treated with conventional radiotherapy technique and chemotherapy. This current study investigates dentofacial long-term effects among HNRMS survivors managed with intensity-modulated radiotherapy (IMRT) and chemotherapy. In general, IMRT is a more effective 3D-conformal radiotherapy technique, which delivers high doses of radiation to the tumor target while minimizing doses received by the surrounding normal tissues. The medical records and radiographs were reviewed to identify the following: 1. Facial asymmetry and jaw hypoplasia. 2. Effects on the dental tissue causing tooth agenesis/hypodontia, root agenesis/stunting/malformation, and/or enamel hypoplasia. 3. Trismus, hyposalivation/xerostomia. Thirteen patients reviewed were evaluated at the dental service. Seven patients presented with facial asymmetry and jaw hypoplasia, 9 patients presented with effects on the dental tissue [root agenesis/stunting/malformation (9), tooth agenesis/hypodontia (7) and enamel hypoplasia (3)] and 7 patients developed trismus and /or xerostomia. All patients with facial asymmetry and jaw hypoplasia also developed dental abnormalities. Patients with dentofacial developmental abnormalities were ≤ 7 years of age at treatment. Our study shows that dentofacial developmental abnormalities are still a burden in the era of IMRT and as prognosis of childhood malignancy improves and more patients become long-term survivors, these late dentofacial sequelae among childhood cancer survivors will be common. To minimize these complications, dental oncologists should be integrated into the care of children with head and neck cancers.

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Section: Discussionmentioning

confidence: 99%

Long-term effect of chemotherapy–intensity-modulated radiation therapy (chemo-IMRT) on dentofacial development in head and neck rhabdomyosarcoma patients

Owosho

Brady

Wolden

et al. 2016

Pediatric Hematology and Oncology

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“…Its prevalence ranges from 7 to 27 % in childhood nasopharyngeal carcinoma survivors [52–54]. Functional sequelae include compromised oral hygiene, poor nutrition, impaired dental care, and difficulties with speech [55–57].…”

Section: Resultsmentioning

confidence: 99%

“…While no studies in children have evaluated the radiation dose associated with trismus, an adult series reported that for each 10 Gy over 40 Gy of radiation to the pterygoid muscle, the probability of trismus increased by 24 % [58]. Adult survivors who received head and neck radiation greater than 50 Gy have the highest risk of trismus [59], and children with nasopharyngeal carcinoma typically receive doses greater than 50 Gy [52–54]. Involvement of the muscles of mastication by head and neck tumors can also increase the risk due to late fibrosis.…”

Section: Resultsmentioning

confidence: 99%

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Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Effinger¹,

Migliorati²,

Hudson³

et al. 2014

Support Care Cancer

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Purpose Multi-modality therapy has resulted in improved survival for childhood malignancies. The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for the surveillance and management of asymptomatic survivors who are at least 2 years from completion of therapy. This review outlines the pathophysiology and risks for oral and dental late effects in pediatric cancer survivors and the rationale for oral and dental screening recommended by the Children’s Oncology Group. Methods An English literature search for oral and dental complications of childhood cancer treatment was undertaken via MEDLINE and encompassed January 1975 to January 2013. Proposed guideline content based on the literature review was approved by a multi-disciplinary panel of survivorship experts and scored according to a modified version of the National Comprehensive Cancer Network “Categories of Consensus” system. Results The Children’s Oncology Group oral-dental pan el selected 85 relevant citations. Childhood cancer therapy may impact tooth development, salivary function, craniofacial development, and temporomandibular joint function placing some childhood cancer survivors at an increased risk for poor oral and dental health. Addition ally, head and neck radiation and hematopoietic stem cell transplantation increase the risk of subsequent ma lignant neoplasms in the oral cavity. Survivors require routine dental care to evaluate for potential side effects and initiate early treatment. Conclusions Certain childhood cancer survivors are at an increased risk for poor oral and dental health. Early identification of oral and dental morbidity and early interventions can optimize health and quality of life.

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“…2 The basis for this division is that there is variance in the examiner's perception of the sound. [1][2][3] Objective tinnitus, or tinnitus from para-auditory sources, is far less common than subjective or sensorineural tinnitus. 2 Although uncommon, objective tinnitus can be debilitating to patients, sometimes resulting in severe social, economic, and psychological sequelae.…”

Section: Radiology Quiz Case 2: Diagnosismentioning

confidence: 99%

Radiology Quiz Case 1—Diagnosis

2004

Arch Otolaryngol Head Neck Surg

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Nasopharyngeal carcinoma in childhood and adolescence

Cited by 59 publications

References 25 publications

Long-term effect of chemotherapy–intensity-modulated radiation therapy (chemo-IMRT) on dentofacial development in head and neck rhabdomyosarcoma patients

Long-term effect of chemotherapy–intensity-modulated radiation therapy (chemo-IMRT) on dentofacial development in head and neck rhabdomyosarcoma patients

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Radiology Quiz Case 1—Diagnosis

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