Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Gioacchini, Federico Maria; Tulli, Michele; Kaleci, Shaniko; Magliulo, Giuseppe; Re, Massimo

doi:10.1007/s00405-016-4154-7

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…A previous study has suggested that future perspectives for clinical research should include prospective and observational cohort studies, which may assess the effects of different risk factors in the development of NPC and the effectiveness of investigational treatments (5). Although previous studies have investigated numerous anticancer drugs including nimotuzumab, oxaliplatin and gemcitabine for the treatment of NPC (6)(7)(8)(9), the therapeutic outcomes are not encouraging so far. Therefore, exploring efficient anticancer agents and the potential underlying molecular mechanisms of cellular migration and metastasis in NPC are required.…”

Section: Introductionmentioning

confidence: 99%

Camptothecin inhibits the progression of NPC by regulating TGF‑β‑induced activation of the PI3K/AKT signaling pathway

Huang

Guan

et al. 2018

Oncol Lett

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Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. In the present study, the efficacy of camptothecin for NPC was investigated and. Additionally, the potential signaling pathway mediated by camptothecin in NPC cells was also examined. The results indicated that the viability and aggressiveness of NPC cells were suppressed by camptothecin treatment in a dose-dependent manner. Camptothecin administration downregulated the expression levels of cell-cycle-associated proteins including cyclin 1, cyclin-dependent kinase (CDK)1 and CDK2 in NPC cells. Expression levels of migration-associated proteins including vimentin, fibronectin and epithelial cadherin were regulated by camptothecin treatment in NPC cells. Additionally, camptothecin inhibited the expression of transforming growth factor-β (TGF-β), phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT), whereas TGF-β overexpression abrogated camptothecin-mediated inhibition of PI3K and AKT expression and camptothecin-mediated inhibition of the viability and aggressiveness of NPC cells. Camptothecin significantly inhibited tumor growth and increased survival times in a mouse model of cancer. In conclusion, these results indicate that camptothecin treatment may inhibit the viability of NPC cells and aggressiveness by regulating the TGF-β-induced PI3K/AKT signaling pathways, which in turn may be a potential molecular target for the treatment of NPC.

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Section: Introductionmentioning

confidence: 99%

Camptothecin inhibits the progression of NPC by regulating TGF‑β‑induced activation of the PI3K/AKT signaling pathway

Huang

Guan

et al. 2018

Oncol Lett

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“…Currently, the preferred treatment consists of a combined regimen of radiation therapy and chemotherapy. It has been demonstrated that in children, neoadjuvant chemotherapy can be used to achieve tumor reduction, improve local tumor control, and treat systemic micrometastases-thus, lowering radiation therapy doses (71). In addition to chemotherapy, interferon-β is used, as it appears to have antitumor effects in patients with Epstein-Barr virus-positive NPC (71,72).…”

Section: Nasopharyngeal Carcinomamentioning

confidence: 99%

Masses of the Nose, Nasal Cavity, and Nasopharynx in Children

2017

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A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. The causes of nasal masses in children include congenital and developmental disorders such as congenital nasolacrimal duct mucocele, dermoid cyst, cephalocele, and nasal neuroglial heterotopia; inflammatory and infectious processes such as mucocele, polyp, and pyogenic granuloma; benign neoplasms such as infantile hemangioma and juvenile nasopharyngeal angiofibroma; malignant lesions such as rhabdomyosarcoma and nasopharyngeal carcinoma; and masses related to prior trauma such as septal hematoma. Although direct visualization, without imaging, is frequently sufficient to diagnose pediatric nasal conditions, in many cases imaging has a key role in the treatment of the affected child. Some of these lesions have characteristic computed tomography and/or magnetic resonance imaging findings, some of them are diagnosed on the basis of the location and imaging findings combined, and others demonstrate nonspecific imaging findings. However, imaging is important for better defining the total extent of the lesion and guiding the clinician in determining whether medical and/or surgical intervention is required. In this article, the authors review the imaging findings of the most common causes-and many of the not-so-common causes-of nasal masses encountered in the pediatric population. RSNA, 2017.

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“…Several clinical features, including age, gender, stage, RT technique, RT dose, and response to chemotherapy can predict the prognosis in children with NPC (5)(6)(7)(8)(9)(10). However, the variable outcomes of patients within heterogeneous subgroups suggest that clinical features alone cannot precisely predict the treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Qiu

Guo

et al. 2020

Front. Oncol.

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Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Cited by 15 publications

References 34 publications

Camptothecin inhibits the progression of NPC by regulating TGF‑β‑induced activation of the PI3K/AKT signaling pathway

Camptothecin inhibits the progression of NPC by regulating TGF‑β‑induced activation of the PI3K/AKT signaling pathway

Masses of the Nose, Nasal Cavity, and Nasopharynx in Children

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

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