Nanoparticles laden in situ gelling system for ocular drug targeting

Kumar, Dheeraj; Jain, Nidhi; Gulati, Neha; Nagaich, Upendra

doi:10.4103/2231-4040.107495

Cited by 51 publications

(39 citation statements)

References 49 publications

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“…The in vitro release data revealed the slow release of LF from nanosuspension formulations for more than 8 h. The highest release percentage was obtained from formula C1 which [43][44][45][46]. It was also observed that formulations containing TPP as the crosslinker showed higher release percentages compared to Fig.…”

Section: In Vitro Release Studiesmentioning

confidence: 66%

Modeling, Optimization, and In Vitro Corneal Permeation of Chitosan-Lomefloxacin HCl Nanosuspension Intended for Ophthalmic Delivery

et al. 2015

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Lomefloxacin HCl (LF) is a widely used fourthgeneration fluoroquinolone antibiotic. Like most drug solutions administered via ocular route, it is usually eliminated by eye protective mechanisms. Chitosan (CS) is a natural polysaccharide polymer with numerous advantages in ocular delivery with, antibacterial, and antifungal properties. The aims were to formulate and optimize LF nanosuspensions (NS) with enhanced antimicrobial activity and prolonged duration using ionic gelation technique. Formulation variables included drug load, CS concentration, crosslinker type (tripolyphosphate and sodium alginate), and concentration. Nanosuspension properties (particle size, zeta potential, polydispersity index, entrapment efficiency, drug release, and permeation through bovine cornea) were evaluated. The artificial neural networks (ANNs) model showed optimum entrapment efficiency of 70.63 % w/w, particle size of 176±0.28 nm, and zeta potential of 13.65 mV. Transmission electron microscopy illustrated the production of well-defined spherical nanoparticles. The nanosuspensions showed prolonged release of LF for more than 8 h and threefold increase in amount permeated through bovine cornea compared to drug solution. Improved antibacterial activity of the nanosuspension was noted where 2-and 3.5-fold decrease in minimum inhibitory concentration (MIC) of drug against Gram-positive and Gram-negative bacteria were observed, respectively. Twofold decrease in minimum bactericidal concentration (MBC) of drug nanosuspension against both types of bacteria was also demonstrated. Histopathological examination showed compatibility of optimized formulation with eye tissues in rabbit model. Therefore, model-optimized LF nanosuspension could be an ideal solution to ocular infections by virtue of their augmented activity, high compatibility, and improved permeability.

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Section: In Vitro Release Studiesmentioning

confidence: 66%

Modeling, Optimization, and In Vitro Corneal Permeation of Chitosan-Lomefloxacin HCl Nanosuspension Intended for Ophthalmic Delivery

et al. 2015

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“…It is known as 'nanoparticle laden in situ gel'. In an extensive review, Kumar et al have described every aspect of this novel formulation [75]. The polymeric nanoparticle-loaded in situ gel provides a sustained and prolonged release.…”

Section: Recent Advances In Ophthalmic Nanoparticulate Drug Delivery mentioning

confidence: 99%

“…These in situ activated gel-forming systems seem to be favoured as they can be administered in a drop form and produce considerably less blurred vision. Owing to its control of drug release, the dosage form is more acceptable by the patients and thus increases the patient compliance [75].…”

Section: Recent Advances In Ophthalmic Nanoparticulate Drug Delivery mentioning

confidence: 99%

Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

Andonova¹

2017

Acrylic Polymers in Healthcare

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One of the most promising strategies to improve the bioavailability of active pharmaceutical ingredients is based on the association of the drug with colloidal carriers, for example, polymeric nanoparticles, which are stable in biological environment, protective for encapsulated substances and able to modulate physicochemical characteristics, drug release and biological behaviour. The synthetic polymers possess unique properties due to their chemical structure. Some of them are characterized with mucoadhesiveness; another can facilitate the penetration through mucous layers; or to be stimuli responsive, providing controlled drug release at the target organ, tissues or cells; and all of them are biocompatible and versatile. These are suitable vehicles of nucleic acids, oligonucleotides, DNA, peptides and proteins. This chapter aims to look at the 'hot spots' in the design of synthetic polymer nanoparticles as an intelligent drug delivery system in terms of biopharmaceutical challenges and in relation to the route of their administration: the non-invasive-oral, transdermal, transmucosal (nasal, buccal/sublingual, vaginal, rectal and ocular) and inhalation routes-and the invasive parenteral route.

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“…At specific pH there is Electrostatic, hydrophobic interaction and Hydrogen bonding takes place, hence leads to inter-diffusion and a conformational change in the polymer results in its swelling. Hence sol to gel transition is pH triggered [30]. Figure 1 shows the in situ gelling phenomena by pH modification of the system.…”

Section: According To Physiological Mechanisms Causing Gelation Of Pomentioning

confidence: 99%

“…It is also called osmotically induced gelation. Ion sensitive polymers are able to crosslink with cations (monovalent, divalant) present in lacrimal fluid on ocular surface and enhance the retention time of drug [30].…”

Section: Poly (N-isopropylacrylamide)mentioning

confidence: 99%

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

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In situ -gelling systems has the great potential in the wide areas of drug delivery. The application areas of such systems are broad and these systems can be formulated not only as gels but also as in situ gelling nanospheres, microspheres and liposomes. To overcome the drawbacks associated with conventional drug delivery systems and take advantages of both solutions and gels, such as accurate dosing, ease of administration of the former and longer precorneal residence of the latter, a newer concept of in situ gelling drug delivery systems was came in light for the first time in the early 1980s. In situ gelling systems are the polymeric solutions which can be administered in solution form and immediately undergoes sol-gel phase transition in to a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration) or application of external triggers. In situ gelling systems seems to have wide applications in ocular therapy. A lot of research is going on in this area proves the fact that in situ gelling systems can be advantageous in the ocular drug delivery. In the present review we will discuss recent researches involving application of in situ gelling polymers, their applications in the various domains of drug delivery and marketed formulations based on in situ gelling systems.

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Nanoparticles laden in situ gelling system for ocular drug targeting

Cited by 51 publications

References 49 publications

Modeling, Optimization, and In Vitro Corneal Permeation of Chitosan-Lomefloxacin HCl Nanosuspension Intended for Ophthalmic Delivery

Modeling, Optimization, and In Vitro Corneal Permeation of Chitosan-Lomefloxacin HCl Nanosuspension Intended for Ophthalmic Delivery

Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

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