Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems

Andonova, Velichka

doi:10.5772/intechopen.69056

Cited by 6 publications

(3 citation statements)

References 91 publications

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“…On the whole, the polymeric NP have created a tremendous interest regarding the encapsulation of EO due to their inherent features including, (1) nanometric size which enhances cellular uptake [67,86], (2) high encapsulation efficiency [66,93], (3) high stability as compared to simple essential oil solutions, (4) protection by the polymeric wall from environmental factors (e.g. light and temperature) [87,90], and (5) bioavailability enhancement [68,111]. The main disadvantage of polymeric nanoparticles is that some traces of toxic organic solvent may remain after evaporation.…”

Section: Textilesmentioning

confidence: 99%

Encapsulation of Essential Oils via Nanoprecipitation Process: Overview, Progress, Challenges and Prospects

et al. 2020

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Essential oils are of paramount importance in pharmaceutical, cosmetic, agricultural, and food areas thanks to their crucial properties. However, stability and bioactivity determine the effectiveness of essential oils. Polymeric nanoencapsulation is a well-established approach for the preservation of essential oils. It offers a plethora of benefits, including improved water solubility, effective protection against degradation, prevention of volatile components evaporation and controlled and targeted release. Among the several techniques used for the design of polymeric nanoparticles, nanoprecipitation has attracted great attention. This review focuses on the most outstanding contributions of nanotechnology in essential oils encapsulation via nanoprecipitation method. We emphasize the chemical composition of essential oils, the principle of polymeric nanoparticle preparation, the physicochemical properties of essential oils loaded nanoparticles and their current applications.

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Section: Textilesmentioning

confidence: 99%

Encapsulation of Essential Oils via Nanoprecipitation Process: Overview, Progress, Challenges and Prospects

et al. 2020

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“…The advantages of synthetic polymeric nanoparticle include easy fabrication and absence of biological contamination. Polycationic polymers have shown better mucoadhesive properties and, as a result, are widely used in mucoadhesive drug delivery [11]. Chitosan is mucoadhesive and soluble only at acidic pH.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

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“…In addition, nanoparticles have superior characteristics such as high surface to mass ratio, good adsorption ability, modifiable selectivity, and easy degradation. Over the years, various synthetic polymers such as poly(lactic-co-glycolic acid) (PLGA), poly(ε-caprolactone), poly(ethylene glycol) (PEG), and poly(N-(2-hydroxypropyl) methacrylamide) (PLG), has been widely used to prepare nano-sized drug carriers [1]. The use of synthetic polymers has several limitations, especially in their high immunogenicity, which causes adverse effects on their long-term use [2,3].…”

Section: Introductionmentioning

confidence: 99%