Encapsulation of Essential Oils via Nanoprecipitation Process: Overview, Progress, Challenges and Prospects

Lammari, Narimane; Louaer, Ouahida; Meniai, Abdeslam Hassen; Elaı̈ssari, Abdelhamid

doi:10.3390/pharmaceutics12050431

Cited by 146 publications

(84 citation statements)

References 101 publications

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“…Nanostructured systems have been designed intending essential oils encapsulation as approach to enhance their bio-availability and bio-efficacy as a result of high cellular uptake and controlled release delivery. According to the literature, polymer-based nano-carriers are extensively used for this purpose and no significant cytotoxicity on the normal growth and the development of cultured diploid human cells were observed [40].…”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens

et al. 2020

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Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The antimicrobial susceptibility of the strains was determined by Vitek ® 2 and confirmed by MALDI-TOF/TOF. The antibacterial activity of CCeo and its synergism with antibiotics was determined using agar disk diffusion, broth microdilution, time-kill, and checkboard methods. The integrity of the bacterial cell membrane in S. marcescens was monitored by protein leakage assay. CCeo exhibited inhibitory effects with MIC = 281.25 μg.mL-1. The association between CCeo and polymyxin B showed a decrease in terms of viable cell counts on survival curves over time after a 4 hour-treatment with a FIC index value of 0.006. Protein leakage was observed with increasing concentrations for CCeo and CCeo + polymyxin B treatments. CCeo showed antibacterial activity against the studied strains. When associated with polymyxin B, a synergistic effect was able to inhibit bacterial growth rapidly and consistently, making it a potential candidate for the development of an alternative treatment and drug delivery system for carbapenemase-producing strains.

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Section: Discussionmentioning

confidence: 99%

Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens

et al. 2020

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“…The first solution, called the solvent phase, cointains the polymer and the active compounds to be encapsulated; the second solution, called the antisolvent phase, consists of a solvent and, optionally, also a surfactant, chosen to be completely soluble with the solvent of the solvent phase and in which the active principles and the polymer are not soluble. In this manner, after the mixing between the solvent and the antisolvent phase, a rapid saturation of the solutes is generated in the solvent phase, followed by nanoparticle precipitation [38].…”

Section: Production Of Zein Nanoparticles Loaded With H Sabdariffa Ementioning

confidence: 99%

Encapsulation of Hibiscus sabdariffa Extract into Zein Nanoparticles

et al. 2020

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A combined approach for the extraction of antioxidants from Hibiscus sabdariffa and entrapment of the extract in zein nanoparticles is proposed. Different green extraction techniques were adopted: high‐pressure and ‐temperature extraction, ultrasound‐assisted extraction, and microwave‐assisted extraction, using an ethanol/water mixture as extracting solvent. The extracts were used for the preparation of zein nanoparticles by liquid antisolvent precipitation. The impacts of process variables were investigated using response surface modeling, demonstrating that the proposed strategy allows high extract encapsulation efficiency, good particle size control, and high particle stability.

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“…However, their utilization is very limited due to low water solubility and less stability due to environmental factors including heat, moisture, and oxygen. Nano-sized formulations have emerged as a viable solution in order to improve water dispersion and protect EOs from degradation [32,33]. They may also prevent evaporation of volatile components and offer controlled and targeted release [33].…”

Section: Discussionmentioning

confidence: 99%

A Nanoparticles based Microbiological Study on the Effect of Rosemary and Ginger Essential Oils against Klebsiella pneumoniae.

Abozahra¹,

Abdelhamid²,

Wen³

et al. 2020

TOMICROJ

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Background: Klebsiella pneumoniae is a nosocomial pathogen in outbreaks of hospital infections. It is one of the major factors for morbidity and mortality in hospitalized patients especially those infected with colistin-resistant pathogens. Many plant essential oils have antimicrobial activities and have been investigated as natural sources to combat multiple antibiotic resistances. Moreover, recent advances in phytonanotechnology have created exciting opportunities for the management of many infections. Objective: This study aims at investigating the antimicrobial and antibiofilm effect of rosemary and ginger essential oil-based nano-sized formulations on colistin resistant K. pneumonia clinical isolates. Methods: Isolation and identification of 30 K. pneumonia isolates from different human samples were done followed by antibiotic susceptibility testing and detection of biofilm gene (mrkD). Examination of the activity of the tested essential oils and their chitosan nanoparticle formulations against the selected isolates was made by determination of their MICs using broth microdilution method followed by biofilm inhibition test and quantitative real-time PCR for the expression of mrkD gene in the presence of the oils and nanoparticles formulations compared to untreated bacterial isolates. Results: Our results showed that the minimum inhibitory concentration of rosemary and ginger oils was 1250 μg/ml, that of nanostructured lipid carrier-rosemary oil and nanostructured lipid carrier-ginger oil was 625 μg/ml and rosemary oil loaded chitosan nanoparticles and ginger oil loaded chitosan nanoparticles possessed minimum inhibitory concentration of 156 μg/ml. Results also revealed complete (100%) inhibition for mrkD gene expression when compared to untreated K. pneumonia. Conclusion: Oil loaded chitosan nanoparticles showed the highest antimicrobial and antibiofilm activity.

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Encapsulation of Essential Oils via Nanoprecipitation Process: Overview, Progress, Challenges and Prospects

Cited by 146 publications

References 101 publications

Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens

Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens

Encapsulation of Hibiscus sabdariffa Extract into Zein Nanoparticles

A Nanoparticles based Microbiological Study on the Effect of Rosemary and Ginger Essential Oils against Klebsiella pneumoniae.

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