Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain, Dharmendra; Kumar, Vikas; Singh, hya; Müllertz, Anette; Bar‐Shalom, Daniel

doi:10.15406/japlr.2016.02.00022

Cited by 44 publications

(32 citation statements)

References 63 publications

(147 reference statements)

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“…Besides, enhancing the residence time of drug at pre-corneal surface dependent on the viscosity of the formulations. 31 Formulation F1 containing 0.3 %w/v Carbopol ® 940 and 0.6 %w/v HPMC E4M was assigned with '-' sign as it is not having gelling ability at the pH of STF (pH 7.4) due to the low viscosity of solution and hence were abandoned for further studies. With increase in the concentration of Carbopol ® and HPMC, the formulations retained their liquid state at room temperature and at the formulated pH and increased the gelling capacity of the formulations upon exposure to pH of STF due to increase in the viscosity of formulations.…”

Section: Gelling Capacitymentioning

confidence: 99%

Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer

Sheshala¹,

Ming²,

Kok³

et al. 2019

IJPER

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Introduction: Topical delivery of eye drops which currently accounts to 90% of available ocular dosage forms are ideal for the treatment of eye diseases but having limitations of poor therapeutic response and low bioavailability. Objectives: The objectives of present research was to develop and characterize sustained release in situ ocular gels containing sufacetamide sodium using pH induced gelling polymers for improved therapeutic response and patient compliance. Methods: In situ gel formulations prepared by dispersion method using Carbopol ® 940/Carbopol ® 934 alone or in combination with hydroxypropyl methylcellulose (HPMC E4M). Formultaions were evaluated for appearance, pH, viscosity, gelling capacity, drug content and in vitro drug release. The optimized formulation was assessed for sterility and antimicrobial efficacy using disk diffusion technique in comparison to commercial eye drops (Albucid ® 10%). Results: The appearance of in situ gels were clear and free flowing in nature however, a viscous clear solution with no flow was produced for formulations consisting of 0.8% w/v Carbopol ® 940/Carbopol ® 934 and 2% w/v HPMC E4M. pH of all the formulations was within the range of 5.9 to 6.7. In situ gels with Carbopol ® 940 demonstrated higher viscosity compared to Carbopol ® 934 and drug release was sustained over a period of 8 hr. The selected formulation containing 0.8% w/v Carbopol ® 940 and 1.5% w/v HPMC E4M passed sterility test and demonstrated similar antimicrobial efficiency compared to commercial product. Conclusion: Carbopol ® /HPMC-based in situ gels have potential to improve patient's compliance by reducing the dosing frequency and could be a viable alternative to commercial product.

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Section: Gelling Capacitymentioning

confidence: 99%

Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer

Sheshala¹,

Ming²,

Kok³

et al. 2019

IJPER

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“…The eye tolerance test was evaluated using HET-CAM (Hen's egg test chorioallantoic membrane). The result of the study was a non-irritating product that provides ciprofloxacin release for 21 h in the treatment of susceptible germs infections [131]. Steps in formation of chitosan-dextran sulfate gel, illustrating the technique described by Jain et al [131].…”

Section: Hydrogels In Situmentioning

confidence: 94%

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Popa¹,

Ghica²,

Dinu-Pîrvu³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.

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“…Several approaches to improve corneal resistance to nasolacrimal drainage have been explored, such as the use of viscosity builders and corneal penetration enhancers by inhibiting p-glycoprotein. If, on the one hand, the effect of viscosity in liquid preparations is limited due to the clearance rate, on the other hand, the overly sensitive nature of the corneal and conjunctival tissues requires imposing caution to prevent toxicity [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications

Zielińska

Soles

Lopes

et al. 2020

Biology

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As an immune-privileged target organ, the eyes have important superficial and internal barriers, protecting them from physical and chemical damage from exogenous and/or endogenous origins that would cause injury to visual acuity or even vision loss. These anatomic, physiological and histologic barriers are thus a challenge for drug access and entry into the eye. Novel therapeutic concepts are highly desirable for eye treatment. The design of an efficient ocular drug delivery system still remains a challenge. Although nanotechnology may offer the ability to detect and treat eye diseases, successful treatment approaches are still in demand. The growing interest in nanopharmaceuticals offers the opportunity to improve ophthalmic treatments. Besides their size, which needs to be critically monitored, nanopharmaceuticals for ophthalmic applications have to be produced under sterilized conditions. In this work, we have revised the different sterilization and depyrogenation methods for ophthalmic nanopharmaceuticals with their merits and drawbacks. The paper also describes clinical sterilization of drugs and the outcomes of inappropriate practices, while recent applications of nanopharmaceuticals for ocular drug delivery are also addressed.

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Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Cited by 44 publications

References 63 publications

Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer

Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications

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